UL44 DNA polymerase processivity subunit [Human betaherpesvirus 5] - Gene

Summary

Go to the top of the page Help

Gene symbol: UL44
Gene description: DNA polymerase processivity subunit
Locus tag: HHV5wtgp048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
Lineage: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Sequence:: NC_006273.2 (56501..57802, complement)

NC_006273.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_006273.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44.
Title: Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44.
Protein-protein interaction analyses demonstrated that pUL34 interacts with the viral proteins IE2, UL44, and UL84, that are essential for viral DNA replication.
Title: pUL34 binding near the human cytomegalovirus origin of lytic replication enhances DNA replication and viral growth.
deletion of the sequences encoding the amino terminus of UL84 affects interaction with UL44 and virus replication unexpectedly, not viral DNA synthesis
Title: A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.
chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
Title: The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44.
Human cytomegalovirus UL44 inhibited the transcriptional activation of p53.
Title: Inhibition of p53 transcriptional activity by human cytomegalovirus UL44.
Viral DNA polymerase subunit UL44 accumulated at the periphery of cell nucleus.
Title: Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.
The authors report here that UL44 is phosphorylated when transiently expressed in mammalian cells and coimmunoprecipitates with cellular kinases.
Title: Multiple phosphorylation sites at the C-terminus regulate nuclear import of HCMV DNA polymerase processivity factor ppUL44.
The results are consistent with UL44 being phosphorylated directly by UL97 during infection, and a crucial role for phosphorylation-mediated nuclear localization of UL44 for viral replication.
Title: Sites and roles of phosphorylation of the human cytomegalovirus DNA polymerase subunit UL44.
the carboxy-terminal segment was crucial for virus replication and for the formation of DNA replication compartments in infected cells
Title: The carboxy-terminal segment of the human cytomegalovirus DNA polymerase accessory subunit UL44 is crucial for viral replication.
Interaction of UL112-113 with UL44 is necessary for efficient viral DNA replication.
Title: Role of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human cytomegalovirus.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

core gene

General protein information

Go to the top of the page Help

Preferred Names: DNA polymerase processivity subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_006273.2 Reference assembly

Range

56501..57802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_081502.1 DNA polymerase processivity subunit [Human betaherpesvirus 5]

See identical proteins and their annotated locations for YP_081502.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

F5HC97

UniProtKB/TrEMBL

A0A076JVJ5, A0A0G2TR64, A0A0G2TRE5, A9YU17, A9YU18, D2K5E9, Q6SW88

Conserved Domains (1) summary

pfam03325
Location:116 → 281

Herpes_PAP; Herpesvirus polymerase accessory protein