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    Cyp12d1-p Cytochrome P450 12d1 proximal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246648, updated on 12-Dec-2024

    Summary

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    Official Symbol
    Cyp12d1-pprovided by FlyBase
    Official Full Name
    Cytochrome P450 12d1 proximalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050489
    Locus tag
    Dmel_CG30489
    See related
    AllianceGenome:FB:FBgn0050489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12d1; 12D1; CG18240; CG30489; Cyp 12d1; CYP12A2; Cyp12d; cyp12d1; Cyp12d1; CYP12D1; cyp12d1-p; CYP12d1-p; Dmel\CG30489
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to DDT. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic/larval midgut primordium; and head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp12d1-p in Genome Data Viewer
    Location:
    47D4-47D4; 2-63 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11117225..11121884, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7004730..7009389, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45228 Neighboring gene luna Neighboring gene long non-coding RNA:CR46409 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12d1 distal Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis. Mitchell CL, et al. PLoS One, 2014. PMID 24695618, Free PMC Article
    2. Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development. Rand MD, et al. Toxicology, 2012 Oct 9. PMID 22699155, Free PMC Article
    3. Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance. Jones RT, et al. Pest Manag Sci, 2010 Oct. PMID 20583201
    4. The biology of insecticidal activity and resistance. Perry T, et al. Insect Biochem Mol Biol, 2011 Jul. PMID 21426939
    5. A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus. Li T, et al. Sci Rep, 2015 Dec 10. PMID 26656663, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyp12d1 is implicated by QTL mapped in both panels of DSPR RILs, is significantly upregulated in the presence of caffeine, and RNAi knockdown robustly decreases caffeine tolerance
      Title: Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in Drosophila.
    2. Transgenic flies, expressing the human ERRa-G allele, constitutively over-express Cyp12d1, Cyp6g2 and Cyp9c1.
      Title: A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster.
    3. The active site of CYP6G1 is significantly smaller than that of CYP6A2 or the CYP3A4.
      Title: Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to DDT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to insecticide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 12d1 proximal
    Names
    CG30489-PA
    CG30489-PB
    Cyp12d1-p-PA
    Cyp12d1-p-PB
    cytochrome P450
    cytochrome P450-12d1
    NP_001286304.1
    NP_610635.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11117225..11121884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299375.1 → NP_001286304.1  cytochrome P450 12d1 proximal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P82712, Q8IH46, Q8T4K3
      UniProtKB/TrEMBL
      A0A0B4LF45
      Conserved Domains (1) summary
      cd11054
      Location:76 → 508
      CYP24A1-like; cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s

    2. NM_136791.6 → NP_610635.4  cytochrome P450 12d1 proximal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610635.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P82712, Q8IH46, Q8T4K3
      UniProtKB/TrEMBL
      A0A0B4LF45
      Related
      FBpp0088437
      Conserved Domains (1) summary
      cd11054
      Location:76 → 508
      CYP24A1-like; cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF45 A0A0B4LF45
    P82712.3 P82712

    Gene LinkOut

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