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    Argl Argininosuccinate lyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3771738, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Arglprovided by FlyBase
    Official Full Name
    Argininosuccinate lyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032076
    Locus tag
    Dmel_CG9510
    See related
    AllianceGenome:FB:FBgn0032076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH06087; CG33085; CG9510; Dmel\CG9510; gh06087
    Summary
    Predicted to enable argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; embryonic proventriculus; embryonic proventriculus inner layer; embryonic/larval midgut; and posterior midgut primordium. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Argl in Genome Data Viewer
    Location:
    29F5-29F5; 2-34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8939725..8942105, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8939725..8942105, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46071 Neighboring gene Tetraspanin 29Fa Neighboring gene Tetraspanin 29Fb Neighboring gene uncharacterized protein Neighboring gene Core 1 Galactosyltransferase A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster. Chandrashekara KT, et al. Age (Dordr), 2014. PMID 25173182, Free PMC Article
    2. Gaining Insights into Diabetic Cardiomyopathy from Drosophila. Diop SB, et al. Trends Endocrinol Metab, 2015 Nov. PMID 26482877, Free PMC Article
    3. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
    4. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
    5. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables argininosuccinate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables argininosuccinate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginine biosynthetic process via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine biosynthetic process via ornithine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    argininosuccinate lyase
    Names
    Argl-PB
    Argl-PC
    Argl-PD
    CG9510-PB
    CG9510-PC
    CG9510-PD
    NP_001027234.1
    NP_001285768.1
    NP_609257.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8939725..8942105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298839.1 → NP_001285768.1  argininosuccinate lyase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z741, Q86BM1, Q9VLG9
      Conserved Domains (2) summary
      cd01359
      Location:30 → 461
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
      PRK00855
      Location:9 → 460
      PRK00855; argininosuccinate lyase; Provisional

    2. NM_135413.3 → NP_609257.3  argininosuccinate lyase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609257.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z741, Q86BM1, Q9VLG9
      Conserved Domains (2) summary
      cd01359
      Location:30 → 461
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
      PRK00855
      Location:9 → 460
      PRK00855; argininosuccinate lyase; Provisional

    3. NM_001032063.2 → NP_001027234.1  argininosuccinate lyase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0Z741, Q86BM1, Q9VLG9
      Conserved Domains (2) summary
      cd01359
      Location:30 → 461
      Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
      PRK00855
      Location:9 → 460
      PRK00855; argininosuccinate lyase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U189 Q5U189
    Q8T444 Q8T444
    Q960C6 Q960C6
    Q9VLG9 Q9VLG9

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