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    His1:CG33855 histone H1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3771991, updated on 9-Dec-2024

    Summary

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    Official Symbol
    His1:CG33855provided by FlyBase
    Official Full Name
    histone H1provided by FlyBase
    Primary source
    FLYBASE:FBgn0053855
    Locus tag
    Dmel_CG33855
    See related
    AllianceGenome:FB:FBgn0053855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33855; Dmel\CG33855
    Summary
    Predicted to enable double-stranded DNA binding activity and nucleosomal DNA binding activity. Predicted to be involved in chromosome condensation and negative regulation of DNA recombination. Predicted to be located in chromatin. Predicted to be part of nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-5 (H1.5 linker histone, cluster member). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See His1:CG33855 in Genome Data Viewer
    Location:
    39E1-39E1; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21521616..21522638)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21521616..21522638)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene histone H4 Neighboring gene histone H3 Neighboring gene histone H2B Neighboring gene histone H2A Neighboring gene small non-coding RNA 430q

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
    2. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosomal DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone H1
    Names
    CG33855-PA
    His1:CG33855-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21521616..21522638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032198.2 → NP_001027369.1  histone H1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB54, Q5BI49
      Conserved Domains (1) summary
      pfam00538
      Location:46 → 118
      Linker_histone; linker histone H1 and H5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4AB54 Q4AB54

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