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    AGTR2 angiotensin II receptor type 2 [ Ovis aries (sheep) ]

    Gene ID: 443335, updated on 5-Mar-2024

    Summary

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    Gene symbol
    AGTR2
    Gene description
    angiotensin II receptor type 2
    See related
    EnsemblRapid:ENSOARG00020024319
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Also known as
    AT2
    Orthologs
    human mouse all
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    Genomic context

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    See AGTR2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) X NC_056080.1 (118536180..118542132)

    Chromosome X - NC_056080.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114111468 Neighboring gene solute carrier family 6 member 14 Neighboring gene cancer/testis antigen 83 Neighboring gene uncharacterized LOC114111217 Neighboring gene protein FAM209-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056080.1 Chromosome X Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway. Axelband F, et al. Regul Pept, 2012 Aug 20. PMID 22561691
    2. Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep. Forhead AJ, et al. J Endocrinol, 2011 Feb. PMID 21097994
    3. Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep. Pulgar VM, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Aug. PMID 19515988, Free PMC Article
    4. Maternal nutrient restriction and the fetal left ventricle: decreased angiotensin receptor expression. Gilbert JS, et al. Reprod Biol Endocrinol, 2005 Jul 14. PMID 16018810, Free PMC Article
    5. Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. Robillard JE, et al. Pediatr Res, 1995 Dec. PMID 8618791

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Angiotensin-(3-4), can interact with AT2R in the basolateral membranes of kidney proximal tubule cells.
      Title: Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.
    2. In the ovine fetus, AT receptor antagonism causes increased renal protein expression of the AT receptor subtype, which, combined with inhibition of AT receptor activity, may be partly responsible for growth retardation of the developing kidney.
      Title: Renal growth retardation following angiotensin II type 1 (AT₁) receptor antagonism is associated with increased AT₂ receptor protein in fetal sheep.
    3. Chronic mild hypoxemia increased binding of angiotensin receptors in brain stem nuclei, decreased spontaneous baroreflex gain, and increased chemoreflex responses to asphyxia in the fetus.
      Title: Mild chronic hypoxemia modifies expression of brain stem angiotensin peptide receptors and reflex responses in fetal sheep.
    4. replacement of thyroid hormone in hypothyroid sheep fetuses can restore renal ANG II receptor and renin expression and secretion to normal
      Title: Thyroid hormone replacement normalizes renal renin and angiotensin receptor expression in thyroidectomized fetal sheep.
    5. Immunoreactive AT2 receptor was decreased in the left ventricle of nutrient restricted fetuses compared to control fetuses. AT1 & AT2 message & protein are not tightly coupled, pointing to post-transcriptional control points in the mid gestation NR fetus.
      Title: Maternal nutrient restriction and the fetal left ventricle: decreased angiotensin receptor expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables angiotensin type II receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type-2 angiotensin II receptor
    Names
    Type-2 angiotensin II receptor
    angiotensin II subtype 2 receptor, AT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056080.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      118536180..118542132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_060408464.1 → XP_060264447.1  type-2 angiotensin II receptor

      UniProtKB/Swiss-Prot
      Q28929, W5PJB5
      UniProtKB/TrEMBL
      A0A6P3TBB4

    2. XM_012107488.4 → XP_011962878.1  type-2 angiotensin II receptor

      See identical proteins and their annotated locations for XP_011962878.1

      UniProtKB/Swiss-Prot
      Q28929, W5PJB5
      UniProtKB/TrEMBL
      A0A6P3TBB4
      Related
      ENSOARP00020031452.1, ENSOART00020037991.2
      Conserved Domains (1) summary
      cd15191
      Location:44 → 328
      7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_042241773.2 → XP_042097707.1  type-2 angiotensin II receptor

      UniProtKB/Swiss-Prot
      Q28929, W5PJB5
      UniProtKB/TrEMBL
      A0A6P3TBB4
      Conserved Domains (1) summary
      cd15191
      Location:44 → 328
      7tmA_AT2R; type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. XR_009598946.1 RNA Sequence

    2. XR_009598945.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28929.2 GenPept UniProtKB/Swiss-Prot:Q28929

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials