ERVFRD-1 endogenous retrovirus group FRD member 1, envelope [Mandrillus leucophaeus (drill)] - Gene

Summary

Gene symbol: ERVFRD-1
Gene description: endogenous retrovirus group FRD member 1, envelope
See related: Ensembl:ENSMLEG00000025643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mandrillus leucophaeus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
Summary: Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]
Orthologs: human all
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Genomic context

Location:: chromosome: Un

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
100	current	Mleu.le_1.0 (GCF_000951045.1)	Unplaced Scaffold	NW_012103809.1 (4630590..4639870, complement)

NW_012103809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_012103809.1 Unplaced Scaffold Reference Mleu.le_1.0

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in syncytium formation by plasma membrane fusion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: syncytin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306048.1 → NP_001292977.1 syncytin-2 precursor

Status: REVIEWED

Source sequence(s)

JYKQ01129788

UniProtKB/TrEMBL

A0A2K5XRR8

Conserved Domains (1) summary

cd09851
Location:380 → 456

HTLV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains

RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mleu.le_1.0

Genomic

NW_012103809.1 Reference Mleu.le_1.0

Range

4630590..4639870 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011989656.1 → XP_011845046.1 syncytin-2

Related

ENSMLEP00000005986.1, ENSMLET00000028082.1

Conserved Domains (1) summary

cd09851
Location:380 → 456

HTLV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains