nrfl-1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nrfl-1
Official Full Name: Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1
Primary source: WormBase:WBGene00006438
Locus tag: CELE_C01F6.6
See related: AllianceGenome:WB:WBGene00006438
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein-membrane adaptor activity. Predicted to be involved in protein localization to plasma membrane. Located in apical plasma membrane. Is expressed in excretory cell; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1) and NHERF2 (NHERF family PDZ scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nrfl-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 14

Sequence:: Chromosome: IV; NC_003282.8 (9119092..9130383)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F23B2.2 (e-PCR)
- UniSTS:316615

F23B2.1 (e-PCR)
- UniSTS:318160

C01F6.6 (e-PCR)
- UniSTS:315357

C01F6.7 (e-PCR)
- UniSTS:307198

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1

NP_001040908.1

Confirmed by transcript evidence

NP_001040909.1

Confirmed by transcript evidence

NP_001040910.1

Confirmed by transcript evidence

NP_001263761.1

Partially confirmed by transcript evidence

NP_001263762.1

Partially confirmed by transcript evidence

NP_001294068.1

Confirmed by transcript evidence

NP_001368467.1

Confirmed by transcript evidence

NP_001380170.1

Confirmed by transcript evidence

NP_741478.1

Confirmed by transcript evidence

NP_741479.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9119092..9130383

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047444.7 → NP_001040909.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040909.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EFP7

Conserved Domains (1) summary

cd00992
Location:11 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001392363.1 → NP_001380170.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd00992
Location:11 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001307139.3 → NP_001294068.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294068.1

Status: REVIEWED

UniProtKB/TrEMBL

X5LQ26

Conserved Domains (1) summary

cd00992
Location:11 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_171410.5 → NP_741478.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741478.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EC64, G5EDM4, G5EE55, G5EFP7, I2HAG6, I2HAI6, Q27GP2, X5LQ26, X5LVA5, X5MBG4

Conserved Domains (1) summary

cd00992
Location:11 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001047443.5 → NP_001040908.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040908.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE55

Conserved Domains (1) summary

cd00992
Location:11 → 91

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_171411.7 → NP_741479.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741479.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EC64

Conserved Domains (1) summary

cd00992
Location:282 → 363

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001276832.5 → NP_001263761.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263761.1

Status: REVIEWED

UniProtKB/TrEMBL

I2HAI6

Conserved Domains (1) summary

cd00992
Location:28 → 109

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001276833.3 → NP_001263762.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263762.1

Status: REVIEWED

UniProtKB/TrEMBL

I2HAG6

Conserved Domains (1) summary

cd00992
Location:40 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001047445.6 → NP_001040910.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040910.1

Status: REVIEWED

UniProtKB/TrEMBL

Q27GP2

Conserved Domains (1) summary

cd00992
Location:5 → 86

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001380397.1 → NP_001368467.1 Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd00992
Location:5 → 86

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...