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    kvs-5 BTB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kvs-5
    Official Full Name
    BTB domain-containing protein
    Primary source
    WormBase:WBGene00021948
    Locus tag
    CELE_Y55F3C.3
    See related
    AllianceGenome:WB:WBGene00021948
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in alcohol dependence; developmental and epileptic encephalopathy 26; and epilepsy. Orthologous to several human genes including KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kvs-5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    17
    Sequence:
    Chromosome: IV; NC_003282.8 (736747..753316)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB domain-containing protein
    NP_001294321.1
    • Confirmed by transcript evidence
    NP_001294322.1
    • Confirmed by transcript evidence
    NP_001294323.1
    • Confirmed by transcript evidence
    NP_001294324.1
    • Confirmed by transcript evidence
    NP_001294325.1
    • Confirmed by transcript evidence
    NP_499978.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      736747..753316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307392.3 → NP_001294321.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294321.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLR3
      Conserved Domains (2) summary
      cd18317
      Location:139 → 228
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:377 → 587
      Ion_trans; Ion transport protein

    2. NM_067577.8 → NP_499978.2  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499978.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XV8
      Conserved Domains (2) summary
      cd18317
      Location:68 → 157
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:298 → 508
      Ion_trans; Ion transport protein

    3. NM_001307396.4 → NP_001294325.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294325.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBB7
      Conserved Domains (2) summary
      cd18317
      Location:76 → 165
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:292 → 498
      Ion_trans; Ion transport protein

    4. NM_001307395.4 → NP_001294324.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PAX5
      Conserved Domains (2) summary
      cd18317
      Location:76 → 165
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:300 → 506
      Ion_trans; Ion transport protein

    5. NM_001307393.3 → NP_001294322.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PR20
      Conserved Domains (2) summary
      cd18317
      Location:76 → 165
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:314 → 524
      Ion_trans; Ion transport protein

    6. NM_001307394.3 → NP_001294323.1  BTB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PE60
      Conserved Domains (2) summary
      cd18317
      Location:76 → 165
      BTB_POZ_Kv; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels
      pfam00520
      Location:306 → 516
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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