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    mct-2 MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein;Monocarboxylate transporter 14 [ Caenorhabditis elegans ]

    Gene ID: 182056, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mct-2
    Official Full Name
    MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein;Monocarboxylate transporter 14
    Primary source
    WormBase:WBGene00015273
    Locus tag
    CELE_C01B4.9
    See related
    AllianceGenome:WB:WBGene00015273
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SLC16A4 (solute carrier family 16 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mct-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (2483004..2494791, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Aldose 1-epimerase Neighboring gene Serpentine Receptor, class D (Delta)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein;Monocarboxylate transporter 14
    NP_001303711.1
    • Predicted
    NP_001303712.1
    • Predicted
    NP_001303713.1
    • Predicted
    NP_503681.2
    • Predicted

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2483004..2494791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071280.2 → NP_503681.2  Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503681.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q966D6, Q9UAT3
      Conserved Domains (1) summary
      cd17352
      Location:45 → 519
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters

    2. NM_001316782.1 → NP_001303711.1  MFS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RFF6
      Conserved Domains (1) summary
      cd17352
      Location:1 → 367
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters

    3. NM_001316783.1 → NP_001303712.1  Monocarboxylate transporter 14 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RDR8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 178
      MFS; Major Facilitator Superfamily

    4. NM_001316784.1 → NP_001303713.1  MFS domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RE14
      Conserved Domains (1) summary
      cl28910
      Location:1 → 47
      MFS; Major Facilitator Superfamily

    RNA

    1. NR_133603.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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