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    Fhip1b FHF complex subunit HOOK interacting protein 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fhip1bprovided by RGD
    Official Full Name
    FHF complex subunit HOOK interacting protein 1Bprovided by RGD
    Primary source
    RGD:1359585
    See related
    EnsemblRapid:ENSRNOG00000017408 AllianceGenome:RGD:1359585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FHIP; Fam160a2
    Summary
    Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be part of FHF complex. Orthologous to human FHIP1B (FHF complex subunit HOOK interacting protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 82.5), Kidney (RPKM 79.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhip1b in Genome Data Viewer
    Location:
    1q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169137866..169160305, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (159718679..159748449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170216505..170238898, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene similar to human chromosome 11 open reading frame 42 Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene uncharacterized LOC108349007 Neighboring gene cholecystokinin B receptor Neighboring gene caveolae associated protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article
    2. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Hoffert JD, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16641100, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94288

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FHF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FHF complex subunit HOOK-interacting protein 1B
    Names
    FTS and Hook-interacting protein
    family with sequence similarity 160, member A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005538.2 → NP_001005538.2  FHF complex subunit HOOK-interacting protein 1B

      See identical proteins and their annotated locations for NP_001005538.2

      Status: VALIDATED

      Source sequence(s)
      BC082011, BP493980, CA339001, CV112456
      UniProtKB/TrEMBL
      A0A8I5ZMH3, A0A8L2UJU3, A6I7H8
      Related
      ENSRNOP00000023502.7, ENSRNOT00000023502.8
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169137866..169160305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229932.5 → XP_006229994.1  FHF complex subunit HOOK-interacting protein 1B isoform X3

      See identical proteins and their annotated locations for XP_006229994.1

      UniProtKB/Swiss-Prot
      Q66H54
      UniProtKB/TrEMBL
      A0A8I5ZMH3
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    2. XM_063285569.1 → XP_063141639.1  FHF complex subunit HOOK-interacting protein 1B isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZMH3

    3. XM_006229931.5 → XP_006229993.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMH3
      Related
      ENSRNOP00000078432.1, ENSRNOT00000106363.2
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein

    4. XM_063285567.1 → XP_063141637.1  FHF complex subunit HOOK-interacting protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZMH3

    5. XM_063285572.1 → XP_063141642.1  FHF complex subunit HOOK-interacting protein 1B isoform X5

    6. XM_008759708.4 → XP_008757930.1  FHF complex subunit HOOK-interacting protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMH3
      Conserved Domains (1) summary
      pfam10257
      Location:97 → 426
      RAI16-like; Retinoic acid induced 16-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H54.1 GenPept UniProtKB/Swiss-Prot:Q66H54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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