Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b12provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 12provided by RGD
Primary source: RGD:708367
See related: EnsemblRapid:ENSRNOG00000009630 AllianceGenome:RGD:708367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including fibronectin binding activity; heparin binding activity; and very-long-chain 3-oxoacyl-CoA reductase activity. Predicted to be involved in fatty acid elongation, saturated fatty acid. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in extracellular matrix. Predicted to be part of fatty acid elongase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 361.8), Liver (RPKM 338.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (100445393..100568898, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (79990048..80113556, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (82924699..83048465, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134631 (e-PCR)
- UniSTS:217910

Hsd17b12 (e-PCR), detects polymorphism
- UniSTS:547442

RH138068 (e-PCR)
- UniSTS:220155

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables very-long-chain 3-oxoacyl-CoA reductase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in fatty acid elongation, saturated fatty acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
part_of fatty acid elongase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: very-long-chain 3-oxoacyl-CoA reductase

Names: 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; KAR; estradiol 17-beta-dehydrogenase 12; smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3

NP_114455.2

EC 1.1.1.330

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032066.2 → NP_114455.2 very-long-chain 3-oxoacyl-CoA reductase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q6P7R8, Q9Z1B9

UniProtKB/TrEMBL

A6HNK4, D3ZPU3

Related

ENSRNOP00000012806.4, ENSRNOT00000012806.9

Conserved Domains (1) summary

cd05356
Location:50 → 289

17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs