Lonrf3 LON peptidase N-terminal domain and ring finger 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lonrf3provided by MGI
Official Full Name: LON peptidase N-terminal domain and ring finger 3provided by MGI
Primary source: MGI:MGI:1921615
See related: Ensembl:ENSMUSG00000016239 AllianceGenome:MGI:1921615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rnf127; 4932412G04Rik; 5730439E01Rik; A830039N02Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Is expressed in telencephalon mantle layer and telencephalon ventricular layer. Orthologous to human LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 2.7), placenta adult (RPKM 2.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 20.72 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (35592011..35630510)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (36328358..36366857)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU023707 (e-PCR)
- UniSTS:160878

NoName (e-PCR)
- UniSTS:238012

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: LON peptidase N-terminal domain and RING finger protein 3

Names: ring finger protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028894.1 → NP_083170.1 LON peptidase N-terminal domain and RING finger protein 3

See identical proteins and their annotated locations for NP_083170.1

Status: VALIDATED

Source sequence(s)

AK016522, AL450395, BC058671, BY740851

Consensus CDS

CCDS30059.1

UniProtKB/Swiss-Prot

Q9D4H7

Related

ENSMUSP00000016383.4, ENSMUST00000016383.10

Conserved Domains (7) summary

COG5152
Location:340 → 498

COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]

cd00162
Location:460 → 499

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl19481
Location:560 → 746

LON; Found in ATP-dependent protease La (LON)

sd00006
Location:244 → 272

TPR; TPR repeat [structural motif]

pfam02190
Location:549 → 750

LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain

pfam13414
Location:243 → 309

TPR_11; TPR repeat

pfam14634
Location:158 → 197

zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

35592011..35630510

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541404.1 → XP_006541467.1 LON peptidase N-terminal domain and RING finger protein 3 isoform X1

Conserved Domains (6) summary

COG5574
Location:456 → 551

PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

TIGR00990
Location:244 → 359

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:244 → 272

TPR; TPR repeat [structural motif]

cd16513
Location:159 → 197

RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family

cd16514
Location:510 → 551

RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family

pfam02190
Location:601 → 802

LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain