prkra.L protein activator of interferon induced protein kinase EIF2AK2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: prkra.L
Official Full Name: protein activator of interferon induced protein kinase EIF2AK2 L homeolog
Primary source: Xenbase:XB-GENE-940708
Locus tag: XELAEV_18044753mg
See related: EnsemblRapid:ENSXLAG00005027541 AllianceGenome:Xenbase:XB-GENE-940708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rax; pact; rbpa; dyt16; prkra; prkra-a; prkra-b
Summary: Predicted to enable double-stranded RNA binding activity and siRNA binding activity. Predicted to act upstream of or within siRNA processing. Predicted to be located in cytoplasm. Predicted to be part of RISC complex and RISC-loading complex. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (79353466..79363624, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (68848193..68858351, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within siRNA processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein activator of interferon induced protein kinase EIF2AK2 L homeolog

Names: double-stranded RNA-binding protein A; interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A; interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B; protein kinase, interferon-inducible double stranded RNA dependent activator; xlRBPA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086031.1 → NP_001079500.1 protein activator of interferon induced protein kinase EIF2AK2 L homeolog

See identical proteins and their annotated locations for NP_001079500.1

Status: PROVISIONAL

Source sequence(s)

BC043873

UniProtKB/Swiss-Prot

Q7ZYA5, Q91836

UniProtKB/TrEMBL

A0A974BZD7

Related

ENSXLAP00005082005.1, ENSXLAT00005083616.1

Conserved Domains (3) summary

smart00358
Location:32 → 96

DSRM; Double-stranded RNA binding motif

cd00048
Location:123 → 189

DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

pfam16482
Location:217 → 302

Staufen_C; Staufen C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

79353466..79363624 complement

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GenBank, FASTA, Sequence Viewer (Graphics)