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    AI1 intron-encoded reverse transcriptase aI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AI1
    Official Full Name
    intron-encoded reverse transcriptase aI1
    Primary source
    SGD:S000007261
    Locus tag
    Q0050
    See related
    AllianceGenome:SGD:S000007261; FungiDB:Q0050; VEuPathDB:Q0050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA-directed DNA polymerase activity. Involved in RNA-templated DNA biosynthetic process; homing of group II introns; and mRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AI1 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (13818..16322)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene intron-encoded DNA endonuclease aI5 alpha Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA splicing in yeast mitochondria: DNA sequence analysis of mit- mutants deficient in the excision of introns aI1 and aI2 of the gene for subunit I of cytochrome c oxidase. van der Veen R, et al. Curr Genet, 1988 Mar. PMID 2838183
    2. Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit. Boguta M, et al. Curr Genet, 1988 Feb. PMID 3286020
    3. Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites. Dickson L, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11687644, Free PMC Article
    4. Pentamidine inhibits mitochondrial intron splicing and translation in Saccharomyces cerevisiae. Zhang Y, et al. RNA, 2000 Jul. PMID 10917591, Free PMC Article
    5. Transposition of group II intron aI1 in yeast and invasion of mitochondrial genes at new locations. Mueller MW, et al. Nature, 1993 Nov 11. PMID 8232557

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA-templated DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homing of group II introns IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homing of group II introns IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    intron-encoded reverse transcriptase aI1
    NP_009310.1
    • Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      13818..16322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009310.1 intron-encoded reverse transcriptase aI1 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009310.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7NYG1, P03875, Q9ZZX5
      UniProtKB/TrEMBL
      G2HKD9
      Conserved Domains (5) summary
      cd00085
      Location:771 → 823
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      cd01651
      Location:311 → 577
      RT_G2_intron; RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable ...
      TIGR04416
      Location:260 → 675
      group_II_RT_mat; group II intron reverse transcriptase/maturase
      pfam01348
      Location:602 → 759
      Intron_maturas2; Type II intron maturase
      cl00275
      Location:3 → 56
      Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03875.2

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