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    Htr5a 5-hydroxytryptamine (serotonin) receptor 5A [ Mus musculus (house mouse) ]

    Gene ID: 15563, updated on 27-Nov-2024

    Summary

    Official Symbol
    Htr5aprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 5Aprovided by MGI
    Primary source
    MGI:MGI:96283
    See related
    Ensembl:ENSMUSG00000039106 AllianceGenome:MGI:96283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htr5
    Summary
    Predicted to enable Gi/o-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in perikaryon. Predicted to be active in dendrite and postsynaptic specialization membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and liver and biliary system. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.1), frontal lobe adult (RPKM 2.0) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Htr5a in Genome Data Viewer
    Location:
    5 B1; 5 13.24 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28046836..28059403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (27841716..27855086)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PAX interacting (with transcription-activation domain) protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3565 Neighboring gene STARR-seq mESC enhancer starr_12707 Neighboring gene STARR-seq mESC enhancer starr_12709 Neighboring gene predicted gene, 20239 Neighboring gene peptidylprolyl isomerase D (cyclophilin D) pseudogene Neighboring gene SPATA31 subfamily H, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables Gi/o-coupled serotonin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 5A
    Names
    5-HT-5
    5-HT-5A
    5-HT5A
    serotonin receptor 5A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420120.1NP_001407049.1  5-hydroxytryptamine receptor 5A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132397
    2. NM_008314.3NP_032340.2  5-hydroxytryptamine receptor 5A isoform 1

      See identical proteins and their annotated locations for NP_032340.2

      Status: VALIDATED

      Source sequence(s)
      AC132397
      Consensus CDS
      CCDS19141.1
      UniProtKB/Swiss-Prot
      P30966, Q3URB0
      Related
      ENSMUSP00000038884.6, ENSMUST00000036227.7
      Conserved Domains (1) summary
      pfam00001
      Location:57338
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      28046836..28059403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)