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    Nck2 NCK adaptor protein 2 [ Dipodomys ordii (Ord's kangaroo rat) ]

    Gene ID: 105999622, updated on 13-Mar-2024

    Summary

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    Gene symbol
    Nck2
    Gene description
    NCK adaptor protein 2
    See related
    Ensembl:ENSDORG00000003648
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Dipodomys ordii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae; Dipodomyinae; Dipodomys
    Orthologs
    human mouse all
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    Genomic context

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    See Nck2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    100 current Dord_2.0 (GCF_000151885.1) Unplaced Scaffold NW_012267410.1 (724023..791797, complement)

    NW_012267410.1Genomic Context describing neighboring genes Neighboring gene UDP-glucuronate decarboxylase 1 Neighboring gene ECRG4 augurin precursor Neighboring gene chromosome unknown open reading frame, human C2orf49 Neighboring gene four and a half LIM domains 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012267410.1 Unplaced Scaffold Reference Dord_2.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Dipodomys ordii Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Dord_2.0

    Genomic

    1. NW_012267410.1 Reference Dord_2.0

      Range
      724023..791797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013034699.1 → XP_012890153.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      A0A1S3GMQ7
      Related
      ENSDORP00000003413.2, ENSDORT00000003648.2
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    2. XM_013034700.1 → XP_012890154.1  cytoplasmic protein NCK2 isoform X2

      UniProtKB/TrEMBL
      A0A1S3GPH0
      Conserved Domains (3) summary
      cd10409
      Location:241 → 338
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11902
      Location:72 → 126
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:156 → 214
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein
    Nucleotide Protein
    Heading Accession and Version

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