U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Marf1 meiosis regulator and mRNA stability 1 [ Mus musculus (house mouse) ]

    Gene ID: 223989, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Marf1provided by MGI
    Official Full Name
    meiosis regulator and mRNA stability 1provided by MGI
    Primary source
    MGI:MGI:2444505
    See related
    Ensembl:ENSMUSG00000060657 AllianceGenome:MGI:2444505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lkap; mKIAA0430; E030019O05; 4921513D23Rik
    Summary
    Predicted to enable CCR4-NOT complex binding activity. Involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Acts upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Is expressed in central nervous system; early conceptus; oocyte; and sensory organ. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 10.6), frontal lobe adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Marf1 in Genome Data Viewer
    Location:
    16 A1; 16 9.69 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13927030..13977157, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14109166..14159278, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene bMERB domain containing 1 Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like Neighboring gene Y box protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7428 Neighboring gene STARR-positive B cell enhancer ABC_E4155 Neighboring gene microRNA 484 Neighboring gene STARR-seq mESC enhancer starr_40176 Neighboring gene nudE neurodevelopment protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Yao Q, et al. Proc Natl Acad Sci U S A, 2018 Oct 30. PMID 30333187, Free PMC Article
    2. Interference with the C-terminal structure of MARF1 causes defective oocyte meiotic division and female infertility in mice. Cao GY, et al. J Biomed Res, 2018 Jan 18. PMID 29353819, Free PMC Article
    3. The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Kanemitsu Y, et al. Sci Rep, 2017 Apr 25. PMID 28442784, Free PMC Article
    4. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Su YQ, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23090997, Free PMC Article
    5. A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Fujitani M, et al. Mol Psychiatry, 2017 Mar. PMID 27378146, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Purified MARF1 cleaved ssRNAs in vitro.
      Title: Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice.
    2. Here, the authors report that meiosis arrest female 1 (MARF1) is an RBP that is expressed during neuronal differentiation. Cortical neurons expressed the somatic form of MARF1 (sMARF1) but not the oocyte form (oMARF1). sMARF1 was enriched in embryonic brains, and its expression level decreased as brain development progressed.
      Title: The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain.
    3. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.
      Title: Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.
    4. MARF1 (4921513D23Rik), by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring
      Title: MARF1 regulates essential oogenic processes in mice.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2)  1 citation
    • Gene trapped (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0430, MGC36956

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    meiosis regulator and mRNA stability factor 1
    Names
    limkain-b1
    meiosis arrest female 1
    meiosis arrest female protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081154.2 → NP_001074623.1  meiosis regulator and mRNA stability factor 1

      Status: VALIDATED

      Source sequence(s)
      AC119853, AC164291
      Consensus CDS
      CCDS37262.1
      UniProtKB/Swiss-Prot
      E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
      Related
      ENSMUSP00000087770.5, ENSMUST00000090300.6
      Conserved Domains (10) summary
      cd09978
      Location:1002 → 1072
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1098 → 1169
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1174 → 1245
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1258 → 1328
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1410 → 1482
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1485 → 1560
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:351 → 493
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:508 → 580
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:785 → 873
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:1334 → 1404
      LabA_like_C; C-terminal domain of LabA_like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      13927030..13977157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522018.4 → XP_006522081.1  meiosis regulator and mRNA stability factor 1 isoform X1

      UniProtKB/Swiss-Prot
      E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
      Conserved Domains (10) summary
      cd09978
      Location:988 → 1058
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1084 → 1155
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1160 → 1231
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1244 → 1314
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1396 → 1468
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1471 → 1546
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd12255
      Location:508 → 580
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:771 → 859
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cd10910
      Location:351 → 473
      PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
      cl14879
      Location:1320 → 1390
      LabA_like_C; C-terminal domain of LabA_like proteins

    2. XM_006522019.3 → XP_006522082.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/Swiss-Prot
      E9QPE4, Q5DU29, Q8BJ34, Q8C6U4, Q8K2E6
      Conserved Domains (10) summary
      cd09978
      Location:1002 → 1072
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1098 → 1169
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1174 → 1245
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1258 → 1328
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1410 → 1482
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1485 → 1560
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd12255
      Location:508 → 580
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:785 → 873
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cd10910
      Location:351 → 473
      PIN_limkain_b1_N_like; N-terminal LabA-like PIN domain of limkain b1 and similar proteins
      cl14879
      Location:1334 → 1404
      LabA_like_C; C-terminal domain of LabA_like proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ34.3 GenPept UniProtKB/Swiss-Prot:Q8BJ34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools