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    mt-Nd4l NADH dehydrogenase 4L, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 17720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mt-Nd4lprovided by MGI
    Official Full Name
    NADH dehydrogenase 4L, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:102497
    See related
    AllianceGenome:MGI:102497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus (strain: C57BL/6J)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ND4L
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in ATP synthesis coupled electron transport and proton transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy and diabetes mellitus. Orthologous to human MT-ND4L (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mt-Nd4l in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) MT (non-nuclear) NC_005089.1 (9877..10173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) MT (non-nuclear) NC_005089.1 (9877..10173)

    Chromosome MT - NC_005089.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 3 Neighboring gene tRNA-Arg Neighboring gene NADH dehydrogenase subunit 4 Neighboring gene tRNA-His Neighboring gene tRNA-Ser Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Revisiting the mouse mitochondrial DNA sequence. Bayona-Bafaluy MP, et al. Nucleic Acids Res, 2003 Sep 15. PMID 12954771, Free PMC Article
    2. Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strains. Yu X, et al. Genome Res, 2009 Jan. PMID 19037013, Free PMC Article
    3. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
    4. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • URF4L

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Names
    NADH dehydrogenase subunit 4L
    NP_904336.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_005089.1 Reference assembly

      Range
      9877..10173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_904336.1 NADH dehydrogenase subunit 4L (mitochondrion) [Mus musculus]

      See identical proteins and their annotated locations for NP_904336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P03903
      UniProtKB/TrEMBL
      A0A0C4G448, Q7JD00, Q7YBV2, Q9MD77
      Related
      ENSMUSP00000081021.1
      Conserved Domains (1) summary
      MTH00107
      Location:1 → 98
      ND4L; NADH dehydrogenase subunit 4L; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03903.2

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