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    gid-8 CTLH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gid-8
    Official Full Name
    CTLH domain-containing protein
    Primary source
    WormBase:WBGene00018757
    Locus tag
    CELE_F53E2.1
    See related
    AllianceGenome:WB:WBGene00018757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in body wall musculature; nervous system; pharynx; reproductive system; and seam cell. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gid-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (1467744..1471105)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Solute carrier family 40 member Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Actin-depolymerizing factor 1 Neighboring gene Actin-depolymerizing factor 2 Neighboring gene non-specific serine/threonine protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CTLH domain-containing protein
    NP_001300116.1
    • Confirmed by transcript evidence
    NP_503424.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1467744..1471105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071023.6 → NP_503424.2  CTLH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503424.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UAU3
      Conserved Domains (4) summary
      smart00667
      Location:168 → 201
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:212 → 264
      CTLH; C-terminal to LisH motif
      smart00757
      Location:260 → 340
      CRA; CT11-RanBPM
      pfam10607
      Location:209 → 342
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    2. NM_001313187.3 → NP_001300116.1  CTLH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUY3
      Conserved Domains (4) summary
      smart00667
      Location:5 → 38
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:49 → 101
      CTLH; C-terminal to LisH motif
      smart00757
      Location:97 → 177
      CRA; CT11-RanBPM
      pfam10607
      Location:46 → 179
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein
    Heading Accession and Version

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