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    snt-5 C2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178631, updated on 27-Dec-2024

    Summary

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    Official Symbol
    snt-5
    Official Full Name
    C2 domain-containing protein
    Primary source
    WormBase:WBGene00004925
    Locus tag
    CELE_R12A1.2
    See related
    AllianceGenome:WB:WBGene00004925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to be located in membrane. Predicted to be active in axon; plasma membrane; and secretory vesicle. Orthologous to several human genes including SYT10 (synaptotagmin 10); SYT3 (synaptotagmin 3); and SYT6 (synaptotagmin 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snt-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (1393112..1411559, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein;Kunitz/Bovine pancreatic trypsin inhibitor domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dense core granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2 domain-containing protein
    NP_001300174.1
    • Confirmed by transcript evidence
    NP_001300175.1
    • Confirmed by transcript evidence
    NP_001300176.1
    • Confirmed by transcript evidence
    NP_503409.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1393112..1411559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071008.5 → NP_503409.1  C2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16700
      Conserved Domains (2) summary
      cd00276
      Location:301 → 442
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:169 → 277
      C2; C2 domain

    2. NM_001313245.4 → NP_001300174.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AY30
      Conserved Domains (2) summary
      cd00276
      Location:234 → 375
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:102 → 210
      C2; C2 domain

    3. NM_001313247.3 → NP_001300176.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV38
      Conserved Domains (2) summary
      cd00276
      Location:269 → 410
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:137 → 245
      C2; C2 domain

    4. NM_001313246.3 → NP_001300175.1  C2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AST7
      Conserved Domains (2) summary
      cd00276
      Location:204 → 345
      C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
      cl14603
      Location:72 → 180
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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