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    hsf1 heat shock transcription factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 58123, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hsf1provided by ZNC
    Official Full Name
    heat shock transcription factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000616-16
    See related
    Ensembl:ENSDARG00000008818 AllianceGenome:ZFIN:ZDB-GENE-000616-16
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    HSF; HSF1c; hsf1a; hsf1b
    Summary
    Enables sequence-specific DNA binding activity. Acts upstream of or within lens development in camera-type eye and response to heat. Predicted to be active in nucleus. Is expressed in brain; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hsf1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (3056417..3084637)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (3115507..3143739)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene HGH1 homolog (S. cerevisiae) Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene scleraxis bHLH transcription factor a Neighboring gene si:ch211-80h18.1 Neighboring gene starmaker

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning of zebrafish (Danio rerio) heat shock factor 2 (HSF2) and similar patterns of HSF2 and HSF1 mRNA expression in brain tissues. Yeh FL, et al. Biochimie, 2006 Dec. PMID 16938384
    2. zHSF1 modulates zper2 expression in zebrafish embryos. Mennetrier L, et al. Chronobiol Int, 2018 Jul. PMID 29509048
    3. HSF1 is essential for the resistance of zebrafish eye and brain tissues to hypoxia/reperfusion injury. Tucker NR, et al. PLoS One, 2011. PMID 21814572, Free PMC Article
    4. Zebrafish HSF4: a novel protein that shares features of both HSF1 and HSF4 of mammals. Swan CL, et al. Cell Stress Chaperones, 2012 Sep. PMID 22528049, Free PMC Article
    5. HSP70, the earliest-induced gene in the zebrafish retina during optic nerve regeneration: its role in cell survival. Nagashima M, et al. Neurochem Int, 2011 Jul. PMID 21338645

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
      Title: Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration.
    2. that zHsf1 plays a positive role in HS-driven expression of zper2 in the dark but seems to act as an attenuator in the presence light
      Title: zHSF1 modulates zper2 expression in zebrafish embryos.
    3. The transcriptional up-regulation of unc45b, hsp90aa1.1 and smyd1b is specific to zebrafish mutants with myosin folding defects, and is not triggered in other zebrafish myopathy models
      Title: Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.
    4. data suggest that HSF1 is involved in regulating constitutive lens specific expression of hsp70 in the embryonic zebrafish
      Title: Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heat shock factor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313736.1 → NP_001300665.1  heat shock factor protein 1

      Status: VALIDATED

      Source sequence(s)
      BX255894, CT574549, EH551245, EH572379
      UniProtKB/TrEMBL
      A0A8M1P7Q5, A4IG27, Q1LXV0
      Related
      ENSDARP00000076789.6, ENSDART00000082353.8
      Conserved Domains (3) summary
      smart00415
      Location:17 → 121
      HSF; heat shock factor
      pfam06546
      Location:244 → 497
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:75 → 185
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      3056417..3084637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293954.4 → XP_009292229.1  heat shock factor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B392, F6P697
      Related
      ENSDARP00000121268.2, ENSDART00000141324.4
      Conserved Domains (3) summary
      smart00415
      Location:17 → 121
      HSF; heat shock factor
      pfam06546
      Location:244 → 523
      Vert_HS_TF; Vertebrate heat shock transcription factor
      cl23789
      Location:75 → 185
      PLN02481; Omega-hydroxypalmitate O-feruloyl transferase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131600.1: Suppressed sequence

      Description
      NM_131600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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