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    PKD2L1 polycystin 2 like 1, transient receptor potential cation channel [ Canis lupus familiaris (dog) ]

    Gene ID: 486838, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PKD2L1provided by VGNC
    Official Full Name
    polycystin 2 like 1, transient receptor potential cation channelprovided by VGNC
    Primary source
    VGNC:VGNC:44601
    See related
    Ensembl:ENSCAFG00845016477
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PKD2L1 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (13514442..13544711, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (13228826..13259097, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (13233508..13263795, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (13061160..13091425, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (13099244..13129512, complement)

    Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA12 Neighboring gene CWF19 like 1, cell cycle control Neighboring gene uncharacterized LOC111092995 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 2 Neighboring gene stearoyl-CoA desaturase Neighboring gene uncharacterized LOC111093080

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables muscle alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polycystic kidney disease 2-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051832.1 Reference ROS_Cfam_1.0

      Range
      13514442..13544711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038440279.1 → XP_038296207.1  polycystic kidney disease 2-like 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573
      Related
      ENSCAFP00845023043.1, ENSCAFT00845029306.1
      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain

    2. XM_038440280.1 → XP_038296208.1  polycystic kidney disease 2-like 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573
      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049288.1 Alternate UMICH_Zoey_3.1

      Range
      13061160..13091425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038514895.1 → XP_038370823.1  polycystic kidney disease 2-like 1 protein isoform X1

      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain

    2. XM_038514896.1 → XP_038370824.1  polycystic kidney disease 2-like 1 protein isoform X2

      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

      Range
      13099244..13129512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038642692.1 → XP_038498620.1  polycystic kidney disease 2-like 1 protein isoform X1

    2. XM_038642693.1 → XP_038498621.1  polycystic kidney disease 2-like 1 protein isoform X2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

      Range
      13233508..13263795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038578525.1 → XP_038434453.1  polycystic kidney disease 2-like 1 protein isoform X3

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573

    2. XM_038578526.1 → XP_038434454.1  polycystic kidney disease 2-like 1 protein isoform X4

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      13228826..13259097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014109140.3 → XP_013964615.1  polycystic kidney disease 2-like 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573
      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain

    2. XM_038460473.1 → XP_038316401.1  polycystic kidney disease 2-like 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A8C0T5V6, A0A8I3P573
      Conserved Domains (2) summary
      pfam08016
      Location:147 → 567
      PKD_channel; Polycystin cation channel
      pfam18109
      Location:702 → 736
      Fer4_24; Ferredoxin I 4Fe-4S cluster domain
    Nucleotide Protein
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