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    rhaA L-rhamnose isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948400, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rhaA
    Official Full Name
    L-rhamnose isomerase
    Primary source
    ECOCYC:EG11867
    Locus tag
    b3903
    See related
    ASAP:ABE-0012736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3896
    Summary
    RhaA also has L- lyxose isomerase activity and is needed for growth on L-lyxose (Badia, 1991). [More information is available at EcoGene: EG11867]. L-rhamnose isomerase catalyzes the first step in the utilization of the deoxyhexose sugar rhamnose. [More information is available at EcoCyc: EG11867].
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    Genomic context

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    Sequence:
    NC_000913.3 (4094723..4095982, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-rhamnose mutarotase Neighboring gene rhamnulose-1-phosphate aldolase Neighboring gene rhamnulokinase Neighboring gene DNA-binding transcriptional activator RhaS Neighboring gene DNA-binding transcriptional activator RhaR Neighboring gene rhamnose/lyxose:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. THE METABOLISM OF L-RHAMNOSE IN ESCHERICHIA COLI. I. L-RHAMNOSE ISOMERASE. TAKAGI Y, et al. Biochim Biophys Acta, 1964 Oct 23. PMID 14243758
    2. The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. Korndörfer IP, et al. J Mol Biol, 2000 Jul 21. PMID 10891278
    3. Identification of the rhaA, rhaB and rhaD gene products from Escherichia coli K-12. Badía J, et al. FEMS Microbiol Lett, 1989 Dec. PMID 2558952
    4. The L-rhamnose genetic system in Escherichia coli K-12. Power J. Genetics, 1967 Mar. PMID 5341476, Free PMC Article
    5. DNA-dependent renaturation of an insoluble DNA binding protein. Identification of the RhaS binding site at rhaBAD. Egan SM, et al. J Mol Biol, 1994 Nov 11. PMID 7966303

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-rhamnose isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-rhamnose isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-rhamnose isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rhamnose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-lyxose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-lyxose metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rhamnose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhamnose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rhamnose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhamnose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-rhamnose isomerase
    YP_026276.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4094723..4095982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026276.1 L-rhamnose isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026276.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2G545
      Conserved Domains (1) summary
      PRK01076
      Location:1 → 419
      PRK01076; L-rhamnose isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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