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    feaR DNA-binding transcriptional activator FeaR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945941, updated on 3-Dec-2024

    Summary

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    Official Symbol
    feaR
    Official Full Name
    DNA-binding transcriptional activator FeaR
    Primary source
    ECOCYC:G6706
    Locus tag
    b1384
    See related
    ASAP:ABE-0004630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1381; maoB; maoX; ydbM
    Summary
    "Phenylethylamine regulator," FeaR, is considered an activator of phenylacetate synthesis from 2-phenylethylamine. [More information is available at EcoCyc: G6706].
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    Genomic context

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    Sequence:
    NC_000913.3 (1446378..1447283, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phospholipid transport factor YdbH Neighboring gene lipoprotein YnbE Neighboring gene DUF1318 domain-containing protein YdbL Neighboring gene phenylacetaldehyde dehydrogenase Neighboring gene copper-containing amine oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli. Yamashita M, et al. J Bacteriol, 1996 May. PMID 8631685, Free PMC Article
    2. Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor. Pasupuleti S, et al. J Bacteriol, 2018 Jan 1. PMID 29038253, Free PMC Article
    3. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli. Zeng J, et al. J Bacteriol, 2013 Nov. PMID 24013633, Free PMC Article
    4. 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression. Hanlon SP, et al. Microbiology (Reading), 1997 Feb. PMID 9043126
    5. Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli. Ferrandez A, et al. FEBS Lett, 1997 Apr 7. PMID 9109378

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study concludes that cross talk between the regulatory systems for virulence and metabolism of aromatic amines may depend upon the ability of QseBC and, to a lesser extent QseF, to regulate feaR as well as genes directly involved in virulence
      Title: Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.
    2. Using genetic, biochemical and computational approaches, authors show that the FeaR binding site is a TGNCA-N8-AAA motif that occurs in 2 copies in the tynA and feaB promoters.
      Title: Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.
    3. N-terminus verified by Edman degradation on complete protein
      Title: maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of primary metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator FeaR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1446378..1447283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415902.1 DNA-binding transcriptional activator FeaR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415902.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QTM7
      Conserved Domains (1) summary
      PRK09685
      Location:1 → 301
      PRK09685; DNA-binding transcriptional activator FeaR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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