svh-2 Tyrosine-protein kinase receptor svh-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: svh-2
Official Full Name: Tyrosine-protein kinase receptor svh-2
Primary source: WormBase:WBGene00020504
Locus tag: CELE_T14E8.1
See related: AllianceGenome:WB:WBGene00020504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including axon regeneration; peptidyl-tyrosine autophosphorylation; and positive regulation of axon regeneration. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including distal tip cell; excretory cell; intestine; muscle cell; and pharynx. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See svh-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 19

Sequence:: Chromosome: X; NC_003284.9 (6553287..6559507)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of svh-2, but not of ddr-2, can suppress the axon regeneration defect observed in svh-11 mutants, suggesting that SVH-11 functions between DDR-2 and SVH-2 in this glycosylation pathway. Furthermore, we found that DDR-2 is N-glycosylated at the Asn-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect.
Title: N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans.
the scaffold protein SHC-1 interacts with both DDR-2 and SVH-2. Furthermore, we demonstrate that overexpression of svh-2 and shc-1 suppresses the delay in axon regeneration observed in ddr-2 mutants, suggesting that DDR-2 functions upstream of SVH-2 and SHC-1
Title: The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration.
We show that PKA-dependent phosphorylation of ETS-4 promotes its complex formation with CEBP-1. Furthermore, activation of both cAMP and Ca2+ signaling is required for activation of svh-2 expression
Title: Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14E8.1 (e-PCR)
- UniSTS:310843

T14E8.3 (e-PCR)
- UniSTS:306619

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Tyrosine-protein kinase receptor svh-2

NP_001024906.1

Confirmed by transcript evidence

NP_001368077.1

Confirmed by transcript evidence

NP_509104.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

6553287..6559507

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029735.6 → NP_001024906.1 Tyrosine-protein kinase receptor svh-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024906.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZU7

Conserved Domains (2) summary

smart00219
Location:735 → 993

TyrKc; Tyrosine kinase, catalytic domain

cd00192
Location:739 → 993

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_076703.8 → NP_509104.1 Tyrosine-protein kinase receptor svh-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509104.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H1AGA1, H2KZU7, Q6AHP3

Conserved Domains (2) summary

smart00219
Location:735 → 993

TyrKc; Tyrosine kinase, catalytic domain

cd00192
Location:739 → 993

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_001381011.2 → NP_001368077.1 Tyrosine-protein kinase receptor svh-2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

smart00219
Location:735 → 993

TyrKc; Tyrosine kinase, catalytic domain