acr-17 AcetylCholine Receptor;Neur_chan_memb domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acr-17
Official Full Name: AcetylCholine Receptor;Neur_chan_memb domain-containing protein
Primary source: WormBase:WBGene00000056
Locus tag: CELE_F53E10.2
See related: AllianceGenome:WB:WBGene00000056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acr-17 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (2608652..2615262)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

F53E10.2 (e-PCR)
- UniSTS:320082

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AcetylCholine Receptor;Neur_chan_memb domain-containing protein

NP_001023961.1

Product from WormBase gene class acr;
Confirmed by transcript evidence

NP_001303731.1

Confirmed by transcript evidence

NP_001303732.1

Confirmed by transcript evidence

NP_001303733.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2608652..2615262

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316802.4 → NP_001303731.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M7RFG1, Q6QWI8

Conserved Domains (3) summary

TIGR00860
Location:23 → 463

LIC; Cation transporter family protein

pfam02931
Location:24 → 245

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:252 → 463

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001028790.7 → NP_001023961.1 AcetylCholine Receptor [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023961.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6F6K3, Q6QWI8

Conserved Domains (3) summary

TIGR00860
Location:23 → 491

LIC; Cation transporter family protein

pfam02931
Location:24 → 245

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:252 → 491

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001316803.3 → NP_001303732.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M7RDU0

Conserved Domains (1) summary

pfam02932
Location:9 → 54

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001316804.3 → NP_001303733.1 Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0M7REC3