scxa scleraxis bHLH transcription factor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scxaprovided by ZNC
Official Full Name: scleraxis bHLH transcription factor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060503-414
See related: Ensembl:ENSDARG00000035695 AllianceGenome:ZFIN:ZDB-GENE-060503-414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TCF15; si:ch211-251g8.3
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within tendon formation. Is expressed in several structures, including bone element; cephalic musculature; fin; myoseptum; and operculohyoid ligament. Orthologous to human SCX (scleraxis bHLH transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (3001428..3009574)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (3060530..3068676)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although scxb mutants show no obvious phenotype, scxa mutant embryos have defects in cranial tendon maturation and muscle misalignment. Mutation of both scleraxis genes results in more severe defects in cranial tendon differentiation, muscle and cartilage dysmorphogenesis and paralysis, and lethality by 2-5 wk, which indicates an essential function of scleraxis for craniofacial development.
Title: Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within tendon formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within tendon formation	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: basic helix-loop-helix transcription factor scleraxis

Names: Sclerax2; bHLH transcription factor scleraxis; scleraxis basic helix-loop-helix transcription factor a; scleraxis homolog a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083069.2 → NP_001076538.2 basic helix-loop-helix transcription factor scleraxis

Status: VALIDATED

Source sequence(s)

BX255894, EH579808, EH611882

UniProtKB/TrEMBL

A0A8M1NCA2

Related

ENSDARP00000115633.1, ENSDART00000145363.2

Conserved Domains (1) summary

pfam00010
Location:85 → 136

HLH; Helix-loop-helix DNA-binding domain