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    tns-1 Tensin homolog [ Caenorhabditis elegans ]

    Gene ID: 172215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tns-1
    Official Full Name
    Tensin homolog
    Primary source
    WormBase:WBGene00006508
    Locus tag
    CELE_M01E11.7
    See related
    AllianceGenome:WB:WBGene00006508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in positive regulation of axon regeneration. Located in axon. Is expressed in several structures, including GABAergic neurons; body wall musculature; enteric muscle; head; and vulval muscle. Orthologous to several human genes including TNS1 (tensin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tns-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    28
    Sequence:
    Chromosome: I; NC_003279.8 (5583407..5607529, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Kinesin motor domain-containing protein Neighboring gene Beta-catenin-like protein 1 N-terminal domain-containing protein Neighboring gene Protein-S-isoprenylcysteine O-methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquitin-like protein 5 Neighboring gene putative V-type proton ATPase subunit G

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tensin regulates pharyngeal pumping in Caenorhabditis elegans. Bruns AN, et al. Biochem Biophys Res Commun, 2020 Feb 12. PMID 31784086, Free PMC Article
    2. C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways. Hisamoto N, et al. J Neurosci, 2019 Jul 17. PMID 31109965, Free PMC Article
    3. Adipocytes control food intake and weight regain via Vacuolar-type H(+) ATPase. Zapata RC, et al. Nat Commun, 2022 Aug 30. PMID 36042358, Free PMC Article
    4. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tensin regulates pharyngeal pumping in Caenorhabditis elegans.
      Title: Tensin regulates pharyngeal pumping in Caenorhabditis elegans.
    2. Tensin-1 plays a critical role in the regulation of axon regeneration by linking SVH-2 and integrin signaling pathways.
      Title: C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of axon regeneration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band HDA PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction HDA PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Tensin homolog
    NP_001305199.1
    • Confirmed by transcript evidence
    NP_001305202.1
    • Confirmed by transcript evidence
    NP_001305203.1
    • Confirmed by transcript evidence
    NP_001305204.1
    • Confirmed by transcript evidence
    NP_001379959.1
    • Confirmed by transcript evidence
    NP_491637.2
    • Confirmed by transcript evidence
    NP_491638.1
    • Confirmed by transcript evidence
    NP_740854.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5583407..5607529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059236.5 → NP_491637.2  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0S4XR26, A0A0S4XR31, A0A0S4XR51, A0A0S4XR69, H2L045, H2L046, H2L047, P92160
      Conserved Domains (3) summary
      cd09927
      Location:1079 → 1189
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:1207 → 1348
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14508
      Location:46 → 203
      PTP_tensin; protein tyrosine phosphatase-like domain of tensins

    2. NM_001392327.1 → NP_001379959.1  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd09927
      Location:674 → 784
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:802 → 943
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    3. NM_059237.7 → NP_491638.1  Tensin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P92160
      Conserved Domains (2) summary
      cd09927
      Location:142 → 252
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:270 → 411
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    4. NM_001318270.3 → NP_001305199.1  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XR31
      Conserved Domains (4) summary
      cd09927
      Location:1042 → 1152
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:1170 → 1311
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cd14508
      Location:9 → 166
      PTP_tensin; protein tyrosine phosphatase-like domain of tensins
      pfam10409
      Location:174 → 298
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    5. NM_001318273.3 → NP_001305202.1  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XR26
      Conserved Domains (2) summary
      cd09927
      Location:295 → 405
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:423 → 564
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    6. NM_001318274.3 → NP_001305203.1  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XR69
      Conserved Domains (2) summary
      cd09927
      Location:42 → 152
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:170 → 311
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    7. NM_001318275.3 → NP_001305204.1  Tensin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4XR51
      Conserved Domains (2) summary
      cd01213
      Location:112 → 253
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cl15255
      Location:1 → 94
      SH2; Src homology 2 (SH2) domain

    8. NM_170867.5 → NP_740854.1  Tensin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L047
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2L045.2

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