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    IRX2 iroquois homeobox 2 [ Gallus gallus (chicken) ]

    Gene ID: 373975, updated on 3-Dec-2024

    Summary

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    Symbol
    IRX2provided by CGNC
    Full Name
    iroquois homeobox 2provided by CGNC
    Primary source
    CGNC:48986
    See related
    Ensembl:ENSGALG00010007907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See IRX2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (86227735..86233257, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (86302286..86307809, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101747569 Neighboring gene uncharacterized LOC121109626 Neighboring gene uncharacterized LOC107052665 Neighboring gene uncharacterized LOC121109799 Neighboring gene uncharacterized LOC107052667 Neighboring gene iroquois homeobox 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. c-Irx2 expression reveals an early subdivision of the neural plate in the chick embryo. Goriely A, et al. Mech Dev, 1999 Sep. PMID 10495288
    2. A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken. Freese NH, et al. PLoS One, 2014. PMID 25372603, Free PMC Article
    3. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. Matsumoto K, et al. Nat Neurosci, 2004 Jun. PMID 15133517
    4. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. Ogura K, et al. Cytogenet Cell Genet, 2001. PMID 11435706
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.
      Title: A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.
    2. Irx2 is expressed in the presumptive cerebellum. When Irx2 is misexpressed with Fgf8, the midbrain develops into cerebellum in conjunction with repression of Otx2 and induction of Gbx2.
      Title: The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iroquois-class homeodomain protein IRX-2
    Names
    iroquois homeobox protein 2
    iroquois homologue 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030336.2 → NP_001025507.1  iroquois-class homeodomain protein IRX-2

      See identical proteins and their annotated locations for NP_001025507.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000042
      UniProtKB/TrEMBL
      A0A8V0Y2L7, F1NMD5, Q9PU52
      Conserved Domains (3) summary
      COG5576
      Location:85 → 175
      COG5576; Homeodomain-containing transcription factor [Transcription]
      PRK12323
      Location:286 → 379
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam05920
      Location:130 → 169
      Homeobox_KN; Homeobox KN domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      86227735..86233257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015282366.4 → XP_015137852.1  iroquois-class homeodomain protein IRX-2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y2L7, F1NMD5, Q9PU52
      Related
      ENSGALP00010010376.1, ENSGALT00010018826.1
      Conserved Domains (3) summary
      COG5576
      Location:85 → 175
      COG5576; Homeodomain-containing transcription factor [Transcription]
      PRK12323
      Location:286 → 379
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam05920
      Location:130 → 169
      Homeobox_KN; Homeobox KN domain

    2. XM_046917128.1 → XP_046773084.1  iroquois-class homeodomain protein IRX-2 isoform X2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      86302286..86307809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910180.1 → XP_046766136.1  iroquois-class homeodomain protein IRX-2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0Y2L7, F1NMD5, Q9PU52

    2. XM_046910181.1 → XP_046766137.1  iroquois-class homeodomain protein IRX-2 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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