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    spast spastin [ Lepisosteus oculatus (spotted gar) ]

    Gene ID: 102692709, updated on 3-Dec-2024

    Summary

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    Gene symbol
    spast
    Gene description
    spastin
    See related
    Ensembl:ENSLOCG00000015939
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Lepisosteus oculatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae; Lepisosteus
    Orthologs
    human zebrafish all
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    Genomic context

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    See spast in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_09 current fLepOcu1.hap2 (GCF_040954835.1) 17 NC_090712.1 (6925088..6948404, complement)
    101 previous assembly LepOcu1 (GCF_000242695.1) Linkage Group LG16 NC_023194.1 (6207450..6230803, complement)

    Chromosome 17 - NC_090712.1Genomic Context describing neighboring genes Neighboring gene vitrin Neighboring gene opsin 6, group member a Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene presenilin 2 Neighboring gene mediator of cell motility 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spastin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_040954835.1-RS_2024_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fLepOcu1.hap2

    Genomic

    1. NC_090712.1 Reference fLepOcu1.hap2

      Range
      6925088..6948404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015362893.2 → XP_015218379.1  spastin isoform X2

      UniProtKB/TrEMBL
      W5NG73
      Conserved Domains (5) summary
      smart00382
      Location:321 → 457
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:95 → 173
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:325 → 453
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:527 → 559
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:288 → 341
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_015362892.2 → XP_015218378.1  spastin isoform X1

      UniProtKB/TrEMBL
      W5NG73
      Related
      ENSLOCP00000019632.1
      Conserved Domains (5) summary
      smart00382
      Location:353 → 489
      AAA; ATPases associated with a variety of cellular activities
      cd02679
      Location:95 → 173
      MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...
      pfam00004
      Location:357 → 485
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:559 → 591
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:320 → 373
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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