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    RPS6KA2 ribosomal protein S6 kinase A2 [ Homo sapiens (human) ]

    Gene ID: 6196, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPS6KA2provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A2provided by HGNC
    Primary source
    HGNC:HGNC:10431
    See related
    Ensembl:ENSG00000071242 MIM:601685; AllianceGenome:HGNC:10431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
    Summary
    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 23.1), lung (RPKM 22.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPS6KA2 in Genome Data Viewer
    Location:
    6q27
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (166409364..166862773, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (167786324..168245548, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (166822852..167276013, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17777 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:166807002-166807185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166813225-166813729 Neighboring gene uncharacterized LOC124901460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25434 Neighboring gene MPC1 divergent transcript Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166848811-166849312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:166863042-166863708 Neighboring gene RPS6KA2 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883011-166883914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883915-166884818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166889542-166890188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166899351-166899851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166903150-166903650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166908262-166908949 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:166917274-166918473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166919624-166920564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166920565-166921504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166946507-166947008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25436 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:166955818-166956418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166956766-166957686 Neighboring gene microRNA 1913 Neighboring gene NANOG hESC enhancer GRCh37_chr6:166965189-166965763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166978541-166979078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:166985773-166986662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993751-166994251 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993250-166993750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166994332-166995152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167032008-167032774 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr6:167034435-167034935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17779 Neighboring gene RNA guanine-7 methyltransferase activating subunit like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17781 Neighboring gene uncharacterized LOC107986671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167068910-167069464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167103273-167103941 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:167107051-167108250 Neighboring gene Sharpr-MPRA regulatory region 5298 Neighboring gene insulin like growth factor 2 mRNA binding protein 3 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:167149720-167150919 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:167155940-167156108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167179935-167180722 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:167184261-167185460 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:167196736-167197935 Neighboring gene uncharacterized LOC124901459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167250099-167250620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167266611-167267589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17782 Neighboring gene MPRA-validated peak6317 silencer Neighboring gene uncharacterized LOC124901461 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167315271-167315770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167316941-167317622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:167317623-167318303 Neighboring gene RPS6KA2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association scan of dental caries in the permanent dentition.
    EBI GWAS Catalog
    Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribosomal protein S6 kinase alpha-2
    Names
    MAP kinase-activated protein kinase 1c
    MAPK-activated protein kinase 1c
    mitogen-activated protein kinase-activated protein kinase 1C
    ribosomal S6 kinase 3
    ribosomal protein S6 kinase, 90kDa, polypeptide 2
    NP_001006933.3
    NP_001305865.2
    NP_001305866.1
    NP_001305867.1
    NP_066958.2
    XP_006715612.1
    XP_047275189.1
    XP_047275190.1
    XP_047275191.1
    XP_054212163.1
    XP_054212164.1
    XP_054212165.1
    XP_054212166.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006932.3NP_001006933.3  ribosomal protein S6 kinase alpha-2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AL022069, AL159163, Z98049
      Consensus CDS
      CCDS34570.1
      UniProtKB/TrEMBL
      A0AAQ5BI00
      Related
      ENSP00000427015.1, ENST00000503859.5
      Conserved Domains (2) summary
      cd05582
      Location:71387
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14178
      Location:419711
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    2. NM_001318936.2NP_001305865.2  ribosomal protein S6 kinase alpha-2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AL022069, AL023775, AL159163, Z98049
      Consensus CDS
      CCDS83148.1
      UniProtKB/TrEMBL
      A0AAQ5BI00, F2Z2J1
      Related
      ENSP00000422435.1, ENST00000510118.5
      Conserved Domains (2) summary
      cd05582
      Location:88404
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14178
      Location:436728
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    3. NM_001318937.2NP_001305866.1  ribosomal protein S6 kinase alpha-2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AB209116, AL022069, BQ029058, DA320139, KJ535080
      UniProtKB/TrEMBL
      A0AAQ5BI00
      Conserved Domains (2) summary
      cd14178
      Location:313605
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
      cl21453
      Location:3281
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001318938.1NP_001305867.1  ribosomal protein S6 kinase alpha-2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1, and initiates translation at a downstream start codon. The encoded isoform (e) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AB209116, AK295674, AL022069, BQ029058, DC402728, Z98049
      Consensus CDS
      CCDS83147.1
      UniProtKB/TrEMBL
      A0AAQ5BI00, B7Z3B5
      Related
      ENSP00000422484.1, ENST00000481261.6
      Conserved Domains (4) summary
      smart00220
      Location:1229
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:1290
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14178
      Location:322614
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
      pfam00069
      Location:326583
      Pkinase; Protein kinase domain
    5. NM_021135.6NP_066958.2  ribosomal protein S6 kinase alpha-2 isoform a

      See identical proteins and their annotated locations for NP_066958.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AB209116, AL022069, BC002363, BQ029058, HY150133
      Consensus CDS
      CCDS5294.1
      UniProtKB/Swiss-Prot
      B3KTK9, Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5
      UniProtKB/TrEMBL
      A0AAQ5BI00
      Related
      ENSP00000265678.4, ENST00000265678.9
      Conserved Domains (4) summary
      smart00220
      Location:59318
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:63379
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14178
      Location:411703
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
      pfam00069
      Location:415672
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      166409364..166862773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419235.1XP_047275191.1  ribosomal protein S6 kinase alpha-2 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BI00, B7Z3B5
    2. XM_047419233.1XP_047275189.1  ribosomal protein S6 kinase alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BI00
    3. XM_047419234.1XP_047275190.1  ribosomal protein S6 kinase alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0AAQ5BI00
      Related
      ENSP00000519662.1, ENST00000714395.1
    4. XM_006715549.4XP_006715612.1  ribosomal protein S6 kinase alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BI00
      Conserved Domains (4) summary
      smart00220
      Location:87346
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:91407
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14178
      Location:439731
      STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
      pfam00069
      Location:443700
      Pkinase; Protein kinase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      167786324..168245548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356191.1XP_054212166.1  ribosomal protein S6 kinase alpha-2 isoform X4

      UniProtKB/TrEMBL
      A0AAQ5BI00, B7Z3B5
    2. XM_054356189.1XP_054212164.1  ribosomal protein S6 kinase alpha-2 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BI00
    3. XM_054356190.1XP_054212165.1  ribosomal protein S6 kinase alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0AAQ5BI00
    4. XM_054356188.1XP_054212163.1  ribosomal protein S6 kinase alpha-2 isoform X1

      UniProtKB/TrEMBL
      A0AAQ5BI00