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    GPR17 G protein-coupled receptor 17 [ Homo sapiens (human) ]

    Gene ID: 2840, updated on 10-Dec-2024

    Summary

    Official Symbol
    GPR17provided by HGNC
    Official Full Name
    G protein-coupled receptor 17provided by HGNC
    Primary source
    HGNC:HGNC:4471
    See related
    Ensembl:ENSG00000144230 MIM:603071; AllianceGenome:HGNC:4471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway and positive regulation of Rho protein signal transduction. Predicted to act upstream of or within negative regulation of inflammatory response to antigenic stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 16.2), endometrium (RPKM 2.8) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPR17 in Genome Data Viewer
    Location:
    2q14.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (127646153..127652639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128081407..128087893)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128403728..128410213)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373609 Neighboring gene myosin VIIB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128335179-128335732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16497 Neighboring gene uncharacterized LOC101927834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128393428-128394374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128394375-128395321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128395322-128396268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128396269-128397214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128406535-128407262 Neighboring gene Sharpr-MPRA regulatory region 7437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128407989-128408715 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:128408716-128409441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128416288-128416788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128419363-128420360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420398-128420938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128420939-128421478 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:128457593-128458792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11936 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:128478937-128480136 Neighboring gene SFT2 domain containing 3 Neighboring gene WD repeat domain 33 Neighboring gene MPRA-validated peak3854 silencer Neighboring gene MPRA-validated peak3855 silencer Neighboring gene MPRA-validated peak3856 silencer Neighboring gene MPRA-validated peak3857 silencer Neighboring gene RNY4 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686M18273

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    uracil nucleotide/cysteinyl leukotriene receptor
    Names
    P2Y-like receptor
    R12
    UDP/CysLT receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161415.2NP_001154887.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

      See identical proteins and their annotated locations for NP_001154887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC039595, DA314295, DA366480
      Consensus CDS
      CCDS2148.1
      UniProtKB/Swiss-Prot
      A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
      UniProtKB/TrEMBL
      B3KX68
      Related
      ENSP00000442982.1, ENST00000544369.5
      Conserved Domains (1) summary
      cd15161
      Location:60336
      7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001161416.2NP_001154888.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

      See identical proteins and their annotated locations for NP_001154888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      BC039595, DA366480
      Consensus CDS
      CCDS92862.1
      UniProtKB/TrEMBL
      B3KX68, G4XH68
      Conserved Domains (1) summary
      pfam00001
      Location:48297
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_001161417.2NP_001154889.1  uracil nucleotide/cysteinyl leukotriene receptor isoform b

      See identical proteins and their annotated locations for NP_001154889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AK292725, BC039595
      Consensus CDS
      CCDS92862.1
      UniProtKB/TrEMBL
      B3KX68, G4XH68
      Related
      ENSP00000508383.1, ENST00000486700.2
      Conserved Domains (1) summary
      pfam00001
      Location:48297
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_005291.3NP_005282.1  uracil nucleotide/cysteinyl leukotriene receptor isoform a

      See identical proteins and their annotated locations for NP_005282.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      BC039595, DA390892, Y12546
      Consensus CDS
      CCDS2148.1
      UniProtKB/Swiss-Prot
      A8K9L0, B2R9X0, Q13304, Q8N5S7, Q9UDZ6, Q9UE21
      UniProtKB/TrEMBL
      B3KX68
      Related
      ENSP00000272644.3, ENST00000272644.7
      Conserved Domains (1) summary
      cd15161
      Location:60336
      7tmA_GPR17; G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      127646153..127652639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      128081407..128087893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)