U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    atoC DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947444, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    atoC
    Official Full Name
    DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC
    Primary source
    ECOCYC:EG11668
    Locus tag
    b2220
    See related
    ASAP:ABE-0007343
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2213
    Summary
    Bifunctional bacterial antizyme AtoC(Az) binds to and inhibits ornithine decarboxylase. [More information is available at EcoGene: EG11668]. AtoC, also known as antizyme protein (Az), is a protein that regulates processes at the transcriptional and posttranslational levels . [More information is available at EcoCyc: EG11668].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2321866..2323251)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator RcsB Neighboring gene histidine kinase RcsC Neighboring gene sensor histidine kinase AtoS Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit alpha Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit beta Neighboring gene short chain fatty acid transporter

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Growth of Escherichia coli on short-chain fatty acids: nature of the uptake system. Salanitro JP, et al. J Bacteriol, 1971 Nov. PMID 4942769, Free PMC Article
    2. [Physiological functions of polyamines and regulation of polyamine content in cells]. Igarashi K. Yakugaku Zasshi, 2006 Jul. PMID 16819267
    3. Involvement of the AtoS-AtoC signal transduction system in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli. Theodorou MC, et al. Biochim Biophys Acta, 2006 Jun. PMID 16564134
    4. Role of fadR and atoC(Con) mutations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in recombinant pha+ Escherichia coli. Rhie HG, et al. Appl Environ Microbiol, 1995 Jul. PMID 7618860, Free PMC Article
    5. Does antizyme exist in Escherichia coli? Ivanov IP, et al. Mol Microbiol, 1998 Sep. PMID 9781887

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the involvement of the AtoSC system in the fatty acids metabolic pathways interplay towards cPHB biosynthesis provides additional perceptions of AtoSC role on E. coli regulatory biochemical processes.
      Title: AtoSC two-component system is involved in cPHB biosynthesis through fatty acid metabolism in E. coli.
    2. AtoC N-terminal receiver domain regulated the biological activities of AtoSC.
      Title: Activation of the AtoSC two-component system in the absence of the AtoC N-terminal receiver domain in E. coli.
    3. Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.(
      Title: Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
    4. Analyses of promoter mutants obtained by in vitro chemical mutagenesis of the atoDAEB promoter verified both the importance of AtoC binding for the inducibility of the promoter by acetoacetate and the sigma54 dependence of atoDAEB expression.
      Title: Interactions of the antizyme AtoC with regulatory elements of the Escherichia coli atoDAEB operon.
    5. The gene products of atoS and atoC constitute a two-component signal transduction system, with some unusual properties, involved in the regulation of the atoDAEB operon.
      Title: Phosphorylation activity of the response regulator of the two-component signal transduction system AtoS-AtoC in E. coli.
    6. These results indicate that the presence of both a functional AtoS-AtoC two-component signal transduction system and a functional atoDAEB operon is critical for the enhanced poly-(R)-3-hydroxybutyrate cPHB biosynthesis in E. coli.
      Title: Involvement of the AtoS-AtoC signal transduction system in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2321866..2323251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416724.1 DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416724.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FYC6, A0A418GRN0
      Conserved Domains (1) summary
      PRK11361
      Location:1 → 457
      PRK11361; acetoacetate metabolism transcriptional regulator AtoC
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.