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    CAS1 cycloartenol synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815275, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAS1
    Official Full Name
    cycloartenol synthase 1
    Primary source
    TAIR:AT2G07050
    Locus tag
    AT2G07050
    See related
    Araport:AT2G07050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cycloartenol synthase 1; CYCLOARTENOL SYNTHASE 1; T4E14.16; T4E14_16
    Summary
    Involved in the biosynthesis of brassinosteroids. Catalyzes the reaction from epoxysqualene to cycloartenol.
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    Genomic context

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    See CAS1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Sequence:
    Chromosome: 2; NC_003071.7 (2924360..2930751)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PUX10 Is a Lipid Droplet-Localized Scaffold Protein That Interacts with CELL DIVISION CYCLE48 and Is Involved in the Degradation of Lipid Droplet Proteins. Kretzschmar FK, et al. Plant Cell, 2018 Sep. PMID 30087207, Free PMC Article
    2. Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis. Babiychuk E, et al. Proc Natl Acad Sci U S A, 2008 Feb 26. PMID 18287026, Free PMC Article
    3. Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen. Corey EJ, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 7505443, Free PMC Article
    4. Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. Gas-Pascual E, et al. PLoS One, 2014. PMID 25343375, Free PMC Article
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We used virus induced gene silencing (VIGS) based on gene specific sequences from a Nicotiana tabacum CAS1 or derived from the solgenomics initiative (http://solgenomics.net/) to challenge the respective roles of CAS1
      Title: Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana.
    2. Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis.
      Title: Allelic mutant series reveal distinct functions for Arabidopsis cycloartenol synthase 1 in cell viability and plastid biogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_126681.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cycloartenol synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pentacyclic triterpenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triterpenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    cycloartenol synthase 1
    NP_178722.1
    • cycloartenol synthase 1 (CAS1); FUNCTIONS IN: cycloartenol synthase activity; INVOLVED IN: pentacyclic triterpenoid biosynthetic process, thylakoid membrane organization, pollen development; LOCATED IN: vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Terpene synthase, conserved site (InterPro:IPR002365), Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Squalene cyclase (InterPro:IPR018333), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: lanosterol synthase 1 (TAIR:AT3G45130.1); Has 2063 Blast hits to 1929 proteins in 563 species: Archae - 2; Bacteria - 902; Metazoa - 86; Fungi - 243; Plants - 616; Viruses - 0; Other Eukaryotes - 214 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2924360..2930751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335311.1 → NP_001325220.1  cycloartenol synthase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W0I8, A0A1P8B2H6

    2. NM_126681.3 → NP_178722.1  cycloartenol synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38605, P92967
      UniProtKB/TrEMBL
      A0A178W0I8
      Conserved Domains (2) summary
      PLN03012
      Location:1 → 755
      PLN03012; Camelliol C synthase
      cd02892
      Location:97 → 749
      SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38605.2

    Gene LinkOut

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