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    bmrR transcriptional regulator (MerR family) [ Bacillus subtilis subsp. subtilis str. 168 ]

    Gene ID: 938676, updated on 6-Oct-2023

    Summary

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    Gene symbol
    bmrR
    Gene description
    transcriptional regulator (MerR family)
    Locus tag
    BSU_24020
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
    Lineage
    Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
    Old locus tag
    BSU24020
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    Genomic context

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    Sequence:
    NC_000964.3 (2495898..2496734)

    NC_000964.3Genomic Context describing neighboring genes Neighboring gene putative lipid kinase BmrU Neighboring gene multidrug-efflux transporter Neighboring gene branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase) Neighboring gene branched-chain alpha-keto acid dehydrogenase E1 subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000964.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription. Fang C, et al. Nat Commun, 2020 Dec 8. PMID 33293519, Free PMC Article
    2. Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. Kumaraswami M, et al. J Mol Biol, 2010 Apr 30. PMID 20230832, Free PMC Article
    3. Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Bachas S, et al. Proc Natl Acad Sci U S A, 2011 Jul 5. PMID 21690368, Free PMC Article
    4. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
    5. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription.
      Title: The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription.
    2. Low shape complementarity, suboptimal packing, and efficient burial of a diverse set of ligands is facilitated by an aromatic docking platform formed by a set of conformationally fixed aromatic residues.
      Title: Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR.
    3. the crystal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E) was reported.
      Title: Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    transcriptional regulator (MerR family)
    NP_390282.2
    • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000964.3 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_390282.2 transcriptional regulator (MerR family) [Bacillus subtilis subsp. subtilis str. 168]

      See identical proteins and their annotated locations for NP_390282.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D1JGE8
      Conserved Domains (2) summary
      cd01107
      Location:6 → 112
      HTH_BmrR; Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator
      COG4978
      Location:121 → 278
      BltR2; Bacterial effector-binding domain [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39075.3

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