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    TMPRSS2 transmembrane serine protease 2 [ Pan paniscus (pygmy chimpanzee) ]

    Gene ID: 100988626, updated on 8-Mar-2024

    Summary

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    Gene symbol
    TMPRSS2
    Gene description
    transmembrane serine protease 2
    See related
    Ensembl:ENSPPAG00000018889
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan paniscus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See TMPRSS2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 22 NC_073271.2 (37547072..37580116, complement)
    RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 21 NC_073270.1 (32401351..32434400, complement)

    Chromosome 22 - NC_073271.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134729727 Neighboring gene MX dynamin like GTPase 1 Neighboring gene small nucleolar RNA SNORA32 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protease serine 2
    Names
    transmembrane protease, serine 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073271.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

      Range
      37547072..37580116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_034947921.4 → XP_034803812.1  transmembrane protease serine 2 isoform X2

      UniProtKB/TrEMBL
      Q3I1V4
      Conserved Domains (3) summary
      cd00112
      Location:113 → 148
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:256 → 487
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:153 → 246
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_034947920.3 → XP_034803811.1  transmembrane protease serine 2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8ZHM4, Q3I1V4
      Conserved Domains (3) summary
      cd00112
      Location:113 → 148
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:256 → 487
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:153 → 246
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein
    Heading Accession and Version

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