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    GLIPR1 GLI pathogenesis related 1 [ Homo sapiens (human) ]

    Gene ID: 11010, updated on 3-Dec-2024

    Summary

    Official Symbol
    GLIPR1provided by HGNC
    Official Full Name
    GLI pathogenesis related 1provided by HGNC
    Primary source
    HGNC:HGNC:17001
    See related
    Ensembl:ENSG00000139278 MIM:602692; AllianceGenome:HGNC:17001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLIPR; RTVP1; CRISP7
    Summary
    This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GLIPR1 in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75480755..75503863)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75455443..75478551)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75874535..75897643)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene uncharacterized LOC124902968 Neighboring gene GLIPR1 like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene GLIPR1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75904602-75905146 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75905147-75905690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:75916502-75917002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:75917003-75917503 Neighboring gene uncharacterized LOC105369844 Neighboring gene KRR1 small subunit processome component homolog Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:76026122-76026705 Neighboring gene Sharpr-MPRA regulatory region 10558 Neighboring gene MPRA-validated peak1837 silencer Neighboring gene uncharacterized LOC107984533 Neighboring gene phosphogluconate dehydrogenase pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    glioma pathogenesis-related protein 1
    Names
    GLI pathogenesis-related 1 (glioma)
    gliPR 1
    protein RTVP-1
    related to testis-specific, vespid, and pathogenesis proteins 1
    testes-specific vespid and pathogenesis protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006851.3NP_006842.2  glioma pathogenesis-related protein 1 precursor

      See identical proteins and their annotated locations for NP_006842.2

      Status: REVIEWED

      Source sequence(s)
      AC022507, AC121761, BC012510, CA421777, CB123261
      Consensus CDS
      CCDS9011.1
      UniProtKB/Swiss-Prot
      A7YET6, F8VUC2, P48060, Q15409, Q969K2
      Related
      ENSP00000266659.3, ENST00000266659.8
      Conserved Domains (1) summary
      cd05385
      Location:32178
      SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75480755..75503863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428131.1XP_047284087.1  glioma pathogenesis-related protein 1 isoform X1

      UniProtKB/TrEMBL
      B4E3S5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75455443..75478551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370841.1XP_054226816.1  glioma pathogenesis-related protein 1 isoform X1

      UniProtKB/TrEMBL
      B4E3S5