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    let-767 Very-long-chain 3-oxooacyl-coA reductase let-767 [ Caenorhabditis elegans ]

    Gene ID: 175895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    let-767
    Official Full Name
    Very-long-chain 3-oxooacyl-coA reductase let-767
    Primary source
    WormBase:WBGene00002891
    Locus tag
    CELE_C56G2.6
    See related
    AllianceGenome:WB:WBGene00002891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables long-chain-fatty-acyl-CoA reductase activity and testosterone dehydrogenase [NAD(P)+] activity. Involved in several processes, including androgen metabolic process; estrogen metabolic process; and long-chain fatty acid biosynthetic process. Located in apical cortex and endoplasmic reticulum. Is expressed in hypodermis; intestine; and pharynx. Used to study obesity. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See let-767 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (6338509..6339955, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Proteasomal ubiquitin receptor ADRM1;Proteasomal ubiquitin receptor ADRM1 homolog Neighboring gene DUF4604 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid homeostasis is essential for a maximal ER stress response. Garcia G, et al. Elife, 2023 Jul 25. PMID 37489956, Free PMC Article
    2. The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans. Kuervers LM, et al. Mol Genet Genomics, 2003 Nov. PMID 12905072
    3. Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases. Desnoyers S, et al. J Endocrinol, 2007 Nov. PMID 17951538
    4. Enzymatic preparation of Crassostrea oyster peptides and their promoting effect on male hormone production. Zhang W, et al. J Ethnopharmacol, 2021 Jan 10. PMID 32918991
    5. LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans. Entchev EV, et al. J Biol Chem, 2008 Jun 20. PMID 18390550

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LET-767 determines lipid droplet protein targeting and lipid homeostasis.
      Title: LET-767 determines lipid droplet protein targeting and lipid homeostasis.
    2. LET-767 is a major 3-ketoacyl-CoA reductase in C. elegans required for the bulk production of monomethyl branched and long chain fatty acids, and the developmental arrest in let-767 (RNAi) worms is caused by the deficiency of the former
      Title: LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.
    3. High conservation of the active site and amino acids responsible for enzymatic activity and substrate selectivity strongly suggests that LET-767 shares a common ancestor with human 17beta-HSD3 and 12.
      Title: Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases.
    4. LET-767 modifies a sterol hormone that is required both for embryogenesis and for later stages of development.
      Title: The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-fatty-acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in estrogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Very-long-chain 3-oxooacyl-coA reductase let-767
    NP_001254935.1
    • Confirmed by transcript evidence
    NP_001254936.1
    • Confirmed by transcript evidence
    NP_001293606.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6338509..6339955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306677.4 → NP_001293606.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      S6FCZ1
      Conserved Domains (2) summary
      cd05356
      Location:64 → 310
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
      pfam00106
      Location:66 → 265
      adh_short; short chain dehydrogenase

    2. NM_001268007.4 → NP_001254936.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1P622, Q09517, S6FCZ1
      Conserved Domains (2) summary
      cd05356
      Location:47 → 289
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
      pfam00106
      Location:49 → 244
      adh_short; short chain dehydrogenase

    3. NM_001268006.3 → NP_001254935.1  Very-long-chain 3-oxooacyl-coA reductase let-767 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1P622
      Conserved Domains (2) summary
      cd05356
      Location:64 → 306
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
      pfam00106
      Location:66 → 261
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09517.2

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