Ankk1 ankyrin repeat and kinase domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankk1provided by MGI
Official Full Name: ankyrin repeat and kinase domain containing 1provided by MGI
Primary source: MGI:MGI:3045301
See related: Ensembl:ENSMUSG00000032257 AllianceGenome:MGI:3045301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9930020N01Rik
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Acts upstream of or within regulation of cell cycle process. Located in cell projection; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeletal musculature. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 26.83 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (49326494..49338341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (49415194..49427041, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study characterized the ANKK1 localization in vivo and in vitro, by using immunolabeling, quantitative real-time PCR and Western blot in the myogenic lineage. Histologic investigations in mice and humans revealed that ANKK1 is expressed in precursors of embryonic and adult muscles. Results show a relationship between ANKK1 gene regulation and the metabolism of muscles during development and in adulthood.
Title: ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

Ankk1 (e-PCR), detects polymorphism
- UniSTS:531043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell cycle process	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: ankyrin repeat and protein kinase domain-containing protein 1

NP_001363880.1

EC 2.7.11.1

NP_766510.1

EC 2.7.11.1

XP_036010896.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376951.1 → NP_001363880.1 ankyrin repeat and protein kinase domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC167980

UniProtKB/TrEMBL

B7ZN83

Conserved Domains (4) summary

PHA02876
Location:364 → 694

PHA02876; ankyrin repeat protein; Provisional

sd00045
Location:403 → 434

ANK; ANK repeat [structural motif]

pfam12796
Location:672 → 742

Ank_2; Ankyrin repeats (3 copies)

cl21453
Location:37 → 305

PKc_like; Protein Kinases, catalytic domain
NM_172922.4 → NP_766510.1 ankyrin repeat and protein kinase domain-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_766510.1

Status: VALIDATED

Source sequence(s)

AC167980

Consensus CDS

CCDS40616.1

UniProtKB/Swiss-Prot

Q8BZ25

Related

ENSMUSP00000034792.6, ENSMUST00000034792.7

Conserved Domains (4) summary

PHA02876
Location:333 → 693

PHA02876; ankyrin repeat protein; Provisional

sd00045
Location:402 → 433

ANK; ANK repeat [structural motif]

pfam12796
Location:671 → 741

Ank_2; Ankyrin repeats (3 copies)

cl21453
Location:37 → 305

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

49326494..49338341 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155003.1 → XP_036010896.1 ankyrin repeat and protein kinase domain-containing protein 1 isoform X1

Conserved Domains (4) summary

PHA02876
Location:286 → 646

PHA02876; ankyrin repeat protein; Provisional

sd00045
Location:355 → 386

ANK; ANK repeat [structural motif]

pfam12796
Location:624 → 694

Ank_2; Ankyrin repeats (3 copies)

cl21453
Location:28 → 258

PKc_like; Protein Kinases, catalytic domain