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    tut tumorous testis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tutprovided by FlyBase
    Official Full Name
    tumorous testisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052364
    Locus tag
    Dmel_CG32364
    See related
    AllianceGenome:FB:FBgn0052364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.705; CG32364; Dmel\CG32364; Tut
    Summary
    Enables RNA binding activity. Involved in male germline stem cell symmetric division and negative regulation of translation. Located in cytoplasm. Is expressed in spermatogonium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tut in Genome Data Viewer
    Location:
    66B13-66C1; 3-22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8209577..8210743, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8202677..8203843, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. Chen D, et al. PLoS Genet, 2014 Nov. PMID 25412508, Free PMC Article
    2. A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis. Zhao T, et al. Cell Death Dis, 2022 Sep 2. PMID 36056003, Free PMC Article
    3. Autophagy is required for spermatogonial differentiation in the Drosophila testis. Varga VB, et al. Biol Futur, 2022 Jun. PMID 35672498
    4. The Drosophila LIN54 homolog Mip120 controls two aspects of oogenesis. Cheng MH, et al. Biol Open, 2017 Jul 15. PMID 28522430, Free PMC Article
    5. The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster. Nazario-Toole AE, et al. J Immunol, 2018 Aug 15. PMID 29997126, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in male germline stem cell symmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tumorous testis
    Names
    CG32364-PA
    tut-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8209577..8210743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168261.3 → NP_729346.1  tumorous testis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729346.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4A4, Q8IQA2
      Related
      FBpp0076443
      Conserved Domains (2) summary
      cd12249
      Location:36 → 115
      RRM1_hnRNPR_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein R (hnRNP R) and similar proteins
      pfam11868
      Location:127 → 169
      DUF3388; Protein of unknown function (DUF3388)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQA2 Q8IQA2

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