PCNA2 Proliferating cell nuclear antigen 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PCNA2provided by FlyBase
Official Full Name: Proliferating cell nuclear antigen 2provided by FlyBase
Primary source: FLYBASE:FBgn0032813
Locus tag: Dmel_CG10262
See related: AllianceGenome:FB:FBgn0032813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10262; Dmel\CG10262; DmPCNA2
Summary: Enables DNA polymerase binding activity and chromatin binding activity. Involved in DNA damage response; response to hydrogen peroxide; and response to methyl methanesulfonate. Located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19582823..19583990, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19582823..19583990, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Characterization of a second proliferating cell nuclear antigen (PCNA2).
Title: Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to methyl methanesulfonate	IDA Inferred from Direct Assay more info	PubMed
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain