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    Acadvl Acyl-CoA dehydrogenase very long chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acadvlprovided by FlyBase
    Official Full Name
    Acyl-CoA dehydrogenase very long chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034432
    Locus tag
    Dmel_CG7461
    See related
    AllianceGenome:FB:FBgn0034432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7461; CG7461; dACADVL; Dmel\CG7461
    Summary
    Predicted to enable fatty-acyl-CoA binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic salivary gland duct; larval muscle system; and salivary gland body primordium. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Acadvl in Genome Data Viewer
    Location:
    56C9-56C10; 2-88 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19305172..19307445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15192677..15194950)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Myb-interacting protein 40 Neighboring gene TAK1-associated binding protein 2 Neighboring gene Endophilin B Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acyl-CoA dehydrogenases: Dynamic history of protein family evolution. Swigonová Z, et al. J Mol Evol, 2009 Aug. PMID 19639238, Free PMC Article
    2. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
    3. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Geuking P, et al. Genetics, 2005 Dec. PMID 16079232, Free PMC Article
    4. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Musselman LP, et al. Dis Model Mech, 2011 Nov. PMID 21719444, Free PMC Article
    5. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA dehydrogenase very long chain
    Names
    Acadvl-PB
    Acadvl-PC
    CG7461-PB
    CG7461-PC
    drosophila very-long chain ACAD
    NP_001286611.1
    NP_611409.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19305172..19307445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299682.1 → NP_001286611.1  Acyl-CoA dehydrogenase very long chain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ2, C9QPI7
      Conserved Domains (2) summary
      cd01161
      Location:45 → 454
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:67 → 446
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    2. NM_137565.3 → NP_611409.2  Acyl-CoA dehydrogenase very long chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611409.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ2, C9QPI7
      Conserved Domains (2) summary
      cd01161
      Location:45 → 454
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:67 → 446
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBJ2 A1ZBJ2

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