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    ABCB7 ATP binding cassette subfamily B member 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ABCB7provided by FlyBase
    Official Full Name
    ATP binding cassette subfamily B member 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035244
    Locus tag
    Dmel_CG7955
    See related
    AllianceGenome:FB:FBgn0035244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7955; dABCB7; DmCG7955; Dmel\CG7955
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in intracellular iron ion homeostasis; iron-sulfur cluster assembly; and iron-sulfur cluster export from the mitochondrion. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ABCB7 in Genome Data Viewer
    Location:
    62A8-62A9; 3-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1618414..1623413)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1618414..1623413)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45814 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. Sooksa-Nguan T, et al. J Biol Chem, 2009 Jan 2. PMID 19001374
    2. Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Sun H, et al. Insect Biochem Mol Biol, 2017 Oct. PMID 28803989
    3. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Bergmann AK, et al. Pediatr Blood Cancer, 2010 Feb. PMID 19731322, Free PMC Article
    4. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Metzendorf C, et al. Biochem J, 2009 Jul 15. PMID 19453295
    5. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Navarro JA, et al. Free Radic Biol Med, 2015 Aug. PMID 25841783

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. No ABCB7 mutations were found among sixty CSA probands examined
      Title: Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in iron-sulfur cluster export from the mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ATP binding cassette subfamily B member 7
    Names
    ABCB7-PA
    ABCB7-PB
    CG7955-PA
    CG7955-PB
    NP_728642.2
    NP_728643.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1618414..1623413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167902.2 → NP_728642.2  ATP binding cassette subfamily B member 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDP0, Q9W0C5
      Related
      FBpp0072637
      Conserved Domains (3) summary
      COG5265
      Location:222 → 717
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:164 → 437
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:485 → 720
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_167903.2 → NP_728643.2  ATP binding cassette subfamily B member 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBW9, Q7KVB1
      Related
      FBpp0072638
      Conserved Domains (3) summary
      COG5265
      Location:188 → 683
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:130 → 403
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:451 → 686
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVA9 Q7KVA9
    Q7KVB1 Q7KVB1
    Q9W0C5 Q9W0C5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.