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    Zfp639 zinc finger protein 639 [ Mus musculus (house mouse) ]

    Gene ID: 67778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp639provided by MGI
    Official Full Name
    zinc finger protein 639provided by MGI
    Primary source
    MGI:MGI:1915028
    See related
    Ensembl:ENSMUSG00000027667 AllianceGenome:MGI:1915028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZASC1; Znf639; ANC-2H01; 6230400O18Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation by host of viral transcription; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; retina nuclear layer; and urinary system. Orthologous to human ZNF639 (zinc finger protein 639). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.7), CNS E14 (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp639 in Genome Data Viewer
    Location:
    3 A3; 3 15.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32564355..32574982)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32510264..32520833)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene predicted gene, 54172 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E6047 Neighboring gene STARR-seq mESC enhancer starr_07337 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6048 Neighboring gene STARR-seq mESC enhancer starr_07340 Neighboring gene STARR-positive B cell enhancer ABC_E2662 Neighboring gene mitofusin 1 Neighboring gene STARR-seq mESC enhancer starr_07342 Neighboring gene guanine nucleotide binding protein (G protein), beta 4 Neighboring gene STARR-seq mESC enhancer starr_07343 Neighboring gene STARR-seq mESC enhancer starr_07344 Neighboring gene STARR-seq mESC enhancer starr_07347 Neighboring gene STARR-seq mESC enhancer starr_07348 Neighboring gene STARR-positive B cell enhancer ABC_E179 Neighboring gene actin-like 6A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZASC1 knockout mice exhibit an early bone marrow-specific defect in murine leukemia virus replication. Seidel S, et al. Virol J, 2013 Apr 24. PMID 23617998, Free PMC Article
    2. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. Bogaerts S, et al. Exp Cell Res, 2005 Nov 15. PMID 16182284
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation by host of viral transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 639
    Names
    zinc finger protein ZASC1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161818.1 → NP_001155290.1  zinc finger protein 639 isoform 1

      See identical proteins and their annotated locations for NP_001155290.1

      Status: VALIDATED

      Source sequence(s)
      AK078000, CO042682
      Consensus CDS
      CCDS17295.1
      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6
      Related
      ENSMUSP00000141341.2, ENSMUST00000193287.6
      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    2. NM_001356625.2 → NP_001343554.1  zinc finger protein 639 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130281
      Consensus CDS
      CCDS17295.1
      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6
      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001429053.1 → NP_001415982.1  zinc finger protein 639 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130281
      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6

    4. NM_001429054.1 → NP_001415983.1  zinc finger protein 639 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130281
      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6

    5. NM_001429055.1 → NP_001415984.1  zinc finger protein 639 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130281
      UniProtKB/TrEMBL
      Q80UZ3

    6. NM_001429056.1 → NP_001415985.1  zinc finger protein 639 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130281
      UniProtKB/TrEMBL
      Q80UZ3

    7. NM_001429057.1 → NP_001415986.1  zinc finger protein 639 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130281
      UniProtKB/TrEMBL
      Q80UZ3

    8. NM_144519.5 → NP_653102.1  zinc finger protein 639 isoform 1

      See identical proteins and their annotated locations for NP_653102.1

      Status: VALIDATED

      Source sequence(s)
      AC130281
      Consensus CDS
      CCDS17295.1
      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6
      Related
      ENSMUSP00000141446.2, ENSMUST00000191783.6
      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      32564355..32574982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163252.1 → XP_036019145.1  zinc finger protein 639 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:364 → 437
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_030252772.1 → XP_030108632.1  zinc finger protein 639 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:364 → 437
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_006535527.5 → XP_006535590.1  zinc finger protein 639 isoform X1

      See identical proteins and their annotated locations for XP_006535590.1

      UniProtKB/Swiss-Prot
      A9X400, Q8BWU9, Q99KZ6
      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    4. XM_006535529.5 → XP_006535592.1  zinc finger protein 639 isoform X1

      Related
      ENSMUSP00000029203.8, ENSMUST00000029203.13
      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    5. XM_030252771.2 → XP_030108631.1  zinc finger protein 639 isoform X2

      Conserved Domains (2) summary
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:364 → 437
      zf-C2H2_8; C2H2-type zinc ribbon

    6. XM_036163250.1 → XP_036019143.1  zinc finger protein 639 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:405 → 425
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:408 → 481
      zf-C2H2_8; C2H2-type zinc ribbon

    7. XM_006535530.5 → XP_006535593.1  zinc finger protein 639 isoform X2

      See identical proteins and their annotated locations for XP_006535593.1

      UniProtKB/TrEMBL
      Q80UZ3
      Conserved Domains (2) summary
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:364 → 437
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KZ6.1 GenPept UniProtKB/Swiss-Prot:Q99KZ6

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