S100a16 S100 calcium binding protein A16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a16provided by MGI
Official Full Name: S100 calcium binding protein A16provided by MGI
Primary source: MGI:MGI:1915110
See related: Ensembl:ENSMUSG00000074457 AllianceGenome:MGI:1915110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S100F; DT1P1A7; 2300002L21Rik
Summary: Enables calcium ion binding activity and identical protein binding activity. Acts upstream of or within response to calcium ion. Located in cytoplasm and nucleus. Is expressed in several structures, including brain ventricular layer; gut; heart; nose; and urinary system. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 66.5), stomach adult (RPKM 63.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.25 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90444561..90450458)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90537254..90543151)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3beta and CK1alpha.
Title: S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α.
The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1alpha/XBP1 pathway in renal tubulointerstitial fibrosis.
Title: The interaction of S100A16 and GRP78 actives endoplasmic reticulum stress-mediated through the IRE1α/XBP1 pathway in renal tubulointerstitial fibrosis.
S100A16-induced adipogenesis is associated with up-regulation of 11 beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Title: S100A16-induced adipogenesis is associated with up-regulation of 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1).
S100A16 regulates liver lipid metabolism through the CaM/CAMKK2/AMPK pathway
Title: S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro.
S100A16 inhibits osteogenesis but stimulates adipogenesis by increasing the transcription of PPARgamma and decreasing the transcription of RUNX2.
Title: S100A16 inhibits osteogenesis but stimulates adipogenesis.
High-calcium diets may lead to nuclear exclusion of S100A16, which results in the inhibition of adipogenesis and enhanced insulin sensitivity.
Title: S100A16 mediation of weight gain attenuation induced by dietary calcium.
This study showed that S100A16 protein is a novel adipogenesis-promoting factor and that increased expression of S100A16 in 3T3-L1 adipocytes can have a negative impact on insulin sensitivity.
Title: Identification of S100A16 as a novel adipogenesis promoting factor in 3T3-L1 cells.
In situ hybridization analysis and immunohistochemistry revealed a widespread distribution in the mouse brain. Furthermore, S100A16 expression was found to be astrocyte-specific
Title: S100A16, a novel calcium-binding protein of the EF-hand superfamily.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Markers

RH136200 (e-PCR)
- UniSTS:210195

AI325039 (e-PCR)
- UniSTS:159150

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to calcium ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356605.1 → NP_001343534.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112, CK623434

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Related

ENSMUSP00000096510.4, ENSMUST00000098911.10

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001356606.1 → NP_001343535.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001356607.1 → NP_001343536.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112, BE137327

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001356608.1 → NP_001343537.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Related

ENSMUSP00000102957.2, ENSMUST00000107334.8

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001356609.1 → NP_001343538.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AA433545, AC160552, AI841112

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Related

ENSMUSP00000102954.2, ENSMUST00000107331.8

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_001356610.1 → NP_001343539.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112, CX213938

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Related

ENSMUSP00000102956.2, ENSMUST00000107333.8

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
NM_026416.3 → NP_080692.1 protein S100-A16

Status: VALIDATED

Source sequence(s)

AC160552, AI841112, CA323788

Consensus CDS

CCDS17536.1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Related

ENSMUSP00000096509.3, ENSMUST00000098910.3

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90444561..90450458

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163254.1 → XP_036019147.1 protein S100-A16 isoform X1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_036163257.1 → XP_036019150.1 protein S100-A16 isoform X1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
XM_036163255.1 → XP_036019148.1 protein S100-A16 isoform X1

UniProtKB/Swiss-Prot

Q3TVE3, Q9D708

Conserved Domains (1) summary

cd05022
Location:6 → 94

S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...