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    Pla2g12b phospholipase A2, group XIIB [ Mus musculus (house mouse) ]

    Gene ID: 69836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g12bprovided by MGI
    Official Full Name
    phospholipase A2, group XIIBprovided by MGI
    Primary source
    MGI:MGI:1917086
    See related
    Ensembl:ENSMUSG00000009646 AllianceGenome:MGI:1917086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fksg71; hlb218; Pla2g13; 2010002E04Rik
    Summary
    Predicted to enable calcium ion binding activity and phospholipase A2 activity. Acts upstream of or within cholesterol homeostasis; low-density lipoprotein particle remodeling; and triglyceride homeostasis. Predicted to be located in extracellular region. Is expressed in alimentary system; liver; liver lobe; and yolk sac endoderm. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 23.7), large intestine adult (RPKM 22.3) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pla2g12b in Genome Data Viewer
    Location:
    10 B4; 10 29.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59239242..59257798)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59403420..59421976)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26769 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene oncoprotein induced transcript 3 Neighboring gene predicted gene, 36318 Neighboring gene mitochondrial calcium uniporter Neighboring gene STARR-seq mESC enhancer starr_26771 Neighboring gene STARR-seq mESC enhancer starr_26772 Neighboring gene predicted gene, 40671

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-κB Pathway to Promote Membrane Nephropathy. Fu L, et al. Kidney Blood Press Res, 2023. PMID 37757774
    2. Pla2g12b drives expansion of triglyceride-rich lipoproteins. Thierer JH, et al. Nat Commun, 2024 Mar 7. PMID 38453914, Free PMC Article
    3. Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B. Chen L, et al. FASEB J, 2019 Jul. PMID 30922124
    4. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB. Guan M, et al. Hepatology, 2011 Feb. PMID 21274867
    5. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Rouault M, et al. Biochemistry, 2003 Oct 7. PMID 14516201

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pla2g12b drives expansion of triglyceride-rich lipoproteins.
      Title: Pla2g12b drives expansion of triglyceride-rich lipoproteins.
    2. PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-kappaB Pathway to Promote Membrane Nephropathy.
      Title: PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of the NF-κB Pathway to Promote Membrane Nephropathy.
    3. ERRgamma transcriptionally regulates the expression of PLA2G12B by binding to its promoter region. In Pla2g12b-null mice, ERRgamma fails to regulate hepatic VLDL-TG secretion and lipid droplets accumulate in the liver. ERRgamma is a novel regulator of hepatic VLDL-TG secretion, which is mediated through the action on PLA2G12B.
      Title: Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B.
    4. FXR regulates serum triglyceride level in part through PLA2G12B.
      Title: Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression.
    5. Low HDL Cholesterol Levels in strain Hlb218 Is Caused by a Mutation at amino acid position 129 in the third exon of Pla2g12b.
      Title: Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that affect HDL cholesterol.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within low-density lipoprotein particle remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    group XIIB secretory phospholipase A2-like protein
    Names
    GXIIB
    group XIIB phospholipase A2
    group XIII secretory phospholipase A2-like protein
    phospholipase A2, group XIII
    sPLA2-GXIIB
    NP_076019.2
    XP_006514124.1
    XP_006514125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023530.2 → NP_076019.2  group XIIB secretory phospholipase A2-like protein precursor

      See identical proteins and their annotated locations for NP_076019.2

      Status: VALIDATED

      Source sequence(s)
      BC021592
      Consensus CDS
      CCDS23864.1
      UniProtKB/Swiss-Prot
      Q99P27
      UniProtKB/TrEMBL
      Q8VC81
      Related
      ENSMUSP00000009790.8, ENSMUST00000009790.14
      Conserved Domains (1) summary
      pfam06951
      Location:18 → 195
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      59239242..59257798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514062.4 → XP_006514125.1  group XIIB secretory phospholipase A2-like protein isoform X2

      Conserved Domains (1) summary
      cl29745
      Location:68 → 210
      Phospholip_A2_3; Prokaryotic phospholipase A2

    2. XM_006514061.3 → XP_006514124.1  group XIIB secretory phospholipase A2-like protein isoform X1

      Conserved Domains (1) summary
      pfam06951
      Location:68 → 244
      PLA2G12; Group XII secretory phospholipase A2 precursor (PLA2G12)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P27.1 GenPept UniProtKB/Swiss-Prot:Q99P27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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