Ankrd53 ankyrin repeat domain 53 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ankrd53provided by MGI
Official Full Name: ankyrin repeat domain 53provided by MGI
Primary source: MGI:MGI:1922555
See related: Ensembl:ENSMUSG00000014747 AllianceGenome:MGI:1922555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930564N15Rik
Summary: Predicted to be involved in mitotic metaphase chromosome alignment; regulation of microtubule cytoskeleton organization; and regulation of mitotic cytokinesis. Predicted to be located in spindle. Predicted to be active in spindle pole. Is expressed in limb mesenchyme. Orthologous to human ANKRD53 (ankyrin repeat domain 53). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 40.0) and CNS E18 (RPKM 1.2) See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83739628..83745336)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83762646..83768354)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ankyrin repeat domain-containing protein 53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029245.3 → NP_083521.2 ankyrin repeat domain-containing protein 53

See identical proteins and their annotated locations for NP_083521.2

Status: VALIDATED

Source sequence(s)

AK016222, AK133099

Consensus CDS

CCDS20284.1

UniProtKB/Swiss-Prot

E9QN79, Q3V0J4

Related

ENSMUSP00000014891.4, ENSMUST00000014891.5

Conserved Domains (3) summary

cd00204
Location:106 → 234

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:115 → 212

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:111 → 142

ANK; ANK repeat [structural motif]