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    GCR1 transcription regulator GCR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCR1
    Official Full Name
    transcription regulator GCR1
    Primary source
    SGD:S000005996
    Locus tag
    YPL075W
    See related
    AllianceGenome:SGD:S000005996; FungiDB:YPL075W; VEuPathDB:YPL075W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPF10; SIT3
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in nucleosome organization; regulation of DNA-templated transcription; and regulation of glycolytic process. Located in nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GCR1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    2
    Sequence:
    Chromosome: XVI; NC_001148.4 (412254..415362)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase Neighboring gene putative AAA family ATPase YTA6 Neighboring gene putative ubiquitin-specific protease UBP16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unigenic evolution: a novel genetic method localizes a putative leucine zipper that mediates dimerization of the Saccharomyces cerevisiae regulator Gcr1p. Deminoff SJ, et al. Genetics, 1995 Dec. PMID 8601472, Free PMC Article
    2. Isolation of GCR1, a major transcription factor of glycolytic genes in Saccharomyces cerevisiae, from Kluyveromyces lactis. Haw R, et al. Yeast, 2001 Jun. PMID 11378900
    3. The yeast protein Gcr1p binds to the PGK UAS and contributes to the activation of transcription of the PGK gene. Henry YA, et al. Mol Gen Genet, 1994 Nov 15. PMID 7808400
    4. Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability. Hossain MA, et al. Mol Cell, 2016 May 5. PMID 27153533, Free PMC Article
    5. Glycolytic gene expression in Saccharomyces cerevisiae: nucleotide sequence of GCR1, null mutants, and evidence for expression. Baker HV. Mol Cell Biol, 1986 Nov. PMID 3025612, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impairment of transcription factor Gcr1p binding motif perturbs OPI3 transcription in Saccharomyces cerevisiae.
      Title: Impairment of transcription factor Gcr1p binding motif perturbs OPI3 transcription in Saccharomyces cerevisiae.
    2. GCR1 gene generates multiple protein isoforms, which are downregulated differentially upon glucose depletion.
      Title: Posttranscriptional Regulation of Gcr1 Expression and Activity Is Crucial for Metabolic Adjustment in Response to Glucose Availability.
    3. Gcr1 regulates the expression of PHO92, and Pho92 is involved in glucose metabolism.
      Title: The expression of PHO92 is regulated by Gcr1, and Pho92 is involved in glucose metabolism in Saccharomyces cerevisiae.
    4. study demonstrates that inositol pyrophosphates control the activity of the major glycolytic transcription factor GCR1
      Title: Influence of inositol pyrophosphates on cellular energy dynamics.
    5. Expression of GCR1, the transcriptional activator of glycolytic enzymes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p.
      Title: Expression of GCR1, the transcriptional activator of glycolytic enzyme genes in the yeast Saccharomyces cerevisiae, is positively autoregulated by Gcr1p.
    6. Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression.
      Title: The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level.
    7. Data show that Rap1/Gcr1/Gcr2 transcriptional activation in yeast cells occurs through a large anchored protein platform, the Nup84 nuclear pore subcomplex.
      Title: Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription from a mobile element promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription regulator GCR1
    NP_015250.1
    • Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      412254..415362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183889.1 → NP_015250.1  TPA: transcription regulator GCR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3U1, P07261
      UniProtKB/TrEMBL
      C8ZIV5
      Conserved Domains (2) summary
      PHA03307
      Location:362 → 616
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam12550
      Location:638 → 730
      GCR1_C; Transcriptional activator of glycolytic enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07261.2

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