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    sufE sulfur carrier protein SufE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946173, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sufE
    Official Full Name
    sulfur carrier protein SufE
    Primary source
    ECOCYC:G6905
    Locus tag
    b1679
    See related
    ASAP:ABE-0005608
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1675; ynhA
    Summary
    SufE is homologous to CsdE, encoded by the gene downstream of csdA. [More information is available at EcoGene: EG13961]. SufE acts as a sulfur acceptor that interacts with and increases the activity of the SufS cysteine desulfurase . [More information is available at EcoCyc: G6905].
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    Genomic context

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    Sequence:
    NC_000913.3 (1758874..1759290, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein lipoprotein Neighboring gene L,D-transpeptidase LdtE Neighboring gene L-cysteine desulfurase Neighboring gene Fe-S cluster scaffold complex subunit SufD Neighboring gene Fe-S cluster scaffold complex subunit SufC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SufE sulfur-acceptor protein contains a conserved core structure that mediates interdomain interactions in a variety of redox protein complexes. Goldsmith-Fischman S, et al. J Mol Biol, 2004 Nov 19. PMID 15522304
    2. SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase. Dai Y, et al. Biochemistry, 2015 Aug 11. PMID 26171726, Free PMC Article
    3. Mechanistic studies of the SufS-SufE cysteine desulfurase: evidence for sulfur transfer from SufS to SufE. Ollagnier-de-Choudens S, et al. FEBS Lett, 2003 Dec 4. PMID 14644425
    4. The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning. Gogar RK, et al. J Biol Chem, 2023 Mar. PMID 36736428, Free PMC Article
    5. High-quality homology models derived from NMR and X-ray structures of E. coli proteins YgdK and Suf E suggest that all members of the YgdK/Suf E protein family are enhancers of cysteine desulfurases. Liu G, et al. Protein Sci, 2005 Jun. PMID 15930006, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The beta-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning.
      Title: The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning.
    2. These results show that dynamic changes may shift SufE to a sulfur-acceptor state that interacts more strongly with SufS.
      Title: SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase.
    3. Studies identified SufE-SufS and SufE-SufB interactions.
      Title: An in vivo method for characterization of protein interactions within sulfur trafficking systems of E. coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfur carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metallo-sulfur cluster assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sulfurtransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfur carrier protein SufE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1758874..1759290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416194.1 sulfur carrier protein SufE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416194.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1QFB9, A0A5B9B124
      Conserved Domains (1) summary
      PRK09296
      Location:1 → 126
      PRK09296; cysteine desulfuration protein SufE
    Nucleotide Protein
    Heading Accession and Version

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