| Expressional variations of Kaiso: an association with pathological characteristics and field cancerization of OSCC. | Expressional variations of Kaiso: an association with pathological characteristics and field cancerization of OSCC.
Ahmed S, Khan S, Qureshi MA, Bukhari U, Anis M, Mughal MN., Free PMC Article | 10/8/2022 |
| Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1. | Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1.
Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D., Free PMC Article | 09/17/2022 |
| A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences. | A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.
Nikolova EN, Stanfield RL, Dyson HJ, Wright PE., Free PMC Article | 01/23/2021 |
| The critical apoptosis regulator KAISO is a p53 target gene that is differently regulated by phosphorylated p53 or acetylated p53, depending on DNA damage responses stage. | Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis.
Choi SH, Koh DI, Cho SY, Kim MK, Kim KS, Hur MW., Free PMC Article | 04/4/2020 |
| Kaiso plays a role in regulating intestinal epithelial cell integrity and function | Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity.
Robinson SC, Chaudhary R, Jiménez-Saiz R, Rayner LGA, Bayer L, Jordana M, Daniel JM., Free PMC Article | 02/8/2020 |
| Kaiso modifies MTG16-driven inflammation and tumorigenesis; this suggests that Kaiso deregulation contributes to MTG16-dependent colitis and Colitis-associated carcinoma phenotypes. | Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma.
Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS., Free PMC Article | 12/21/2019 |
| EGFR-Kaiso signaling axis is a critical regulator of the miR-200-ZEB1 feedback loop promoting epithelial to mesenchymal transition and metastasis in prostate cancer. | Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c.
Abisoye-Ogunniyan A, Lin H, Ghebremedhin A, Salam AB, Karanam B, Theodore S, Jones-Trich J, Davis M, Grizzle W, Wang H, Yates C., Free PMC Article | 09/14/2019 |
| Genomic editing of Kaiso by conversion of K42 into R42 (K42R) in HEK293 cells that resulted in fully deSUMOylated endogenous protein led to misregulation of genes associated with ion transport, blood pressure, and the immune response. | DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress.
Zhenilo S, Deyev I, Litvinova E, Zhigalova N, Kaplun D, Sokolov A, Mazur A, Prokhortchouk E., Free PMC Article | 09/7/2019 |
| that Kaiso can inhibit endothelial apoptosis via differentially regulating expression of BCL2, BAX, and BIK and that methylated DNA and specific Kaiso binding site (KBS) contribute to the gene regulatory activity of Kaiso. | Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Xue X, Zhang J, Lan H, Xu Y, Wang H., Free PMC Article | 02/23/2019 |
| The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines. Moreover, decreased expression of miR-4262 was closely related to increased expression of Kaiso (ZBTB33). | Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells.
Feng J., Free PMC Article | 12/22/2018 |
| extracellular microenvironment signals regulate RhoH and Kaiso to modulate actin-cytoskeleton structure and transcriptional activity during T cell migration | RhoH participates in a multi-protein complex with the zinc finger protein kaiso that regulates both cytoskeletal structures and chemokine-induced T cells.
Mino A, Troeger A, Brendel C, Cantor A, Harris C, Ciuculescu MF, Williams DA., Free PMC Article | 11/3/2018 |
| data show that Kaiso favors an mCpG over a CpG site by 2 orders of magnitude in affinity and that an important component of this effect is the presence of hydrophobic and CH...O contacts involving E535. | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso.
Nikolova EN, Stanfield RL, Dyson HJ, Wright PE., Free PMC Article | 05/12/2018 |
| High levels of nuclear Kaiso expression were detected in patients with a higher degree of African heritage compared to their Caucasian counterparts, suggesting a role for Kaiso in triple-negative breast cancer racial disparity. | Kaiso is highly expressed in TNBC tissues of women of African ancestry compared to Caucasian women.
Bassey-Archibong BI, Hercules SM, Rayner LGA, Skeete DHA, Smith Connell SP, Brain I, Daramola A, Banjo AAF, Byun JS, Gardner K, Dushoff J, Daniel JM., Free PMC Article | 05/5/2018 |
| Kaiso promotes Jagged-1 expression, which may have implications in Notch-mediated colon cancer progression | Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells.
Robinson SC, Klobucar K, Pierre CC, Ansari A, Zhenilo S, Prokhortchouk E, Daniel JM., Free PMC Article | 03/3/2018 |
| A role for Kaiso in the proliferation. | Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells.
Bassey-Archibong BI, Rayner LG, Hercules SM, Aarts CW, Dvorkin-Gheva A, Bramson JL, Hassell JA, Daniel JM., Free PMC Article | 11/18/2017 |
| the pathological features of the metastatic activity of parental (Kaisopositive) versus Kaisodepleted MDA-231 cells, are reported. | Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis.
Kwiecien JM, Bassey-Archibong BI, Dabrowski W, Rayner LG, Lucas AR, Daniel JM., Free PMC Article | 10/21/2017 |
| Suggest a role for Kaiso in the progression of pancreatic ductal adenocarcinomas, involving the epithelial mesenchymal transformation markers, E-cadherin and Zeb1. | African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression.
Jones J, Mukherjee A, Karanam B, Davis M, Jaynes J, Reams RR, Dean-Colomb W, Yates C., Free PMC Article | 07/29/2017 |
| a novel mechanism by which ZBTB33 mediates the cyclin D1/cyclin E1/RB1/E2F pathway, controlling passage through the G1 restriction point and accelerating cancer cell proliferation. | Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1.
Pozner A, Terooatea TW, Buck-Koehntop BA., Free PMC Article | 05/27/2017 |
| GR is a putative target gene of Kaiso. | Kaiso represses the expression of glucocorticoid receptor via a methylation-dependent mechanism and attenuates the anti-apoptotic activity of glucocorticoids in breast cancer cells.
Zhou L, Zhong Y, Yang FH, Li ZB, Zhou J, Liu XH, Li M, Hu F., Free PMC Article | 01/28/2017 |
| Kaiso high expression correlated with invasion of prostate cancer. | Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.
Wang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M, Yates C., Free PMC Article | 12/17/2016 |
| Results show that Kaiso binding to unmethylated Kaiso binding site in the human ICR1 is necessary for ICR1 methylation maintenance and affects transcription rates of the lncRNA H19. | Kaiso mediates human ICR1 methylation maintenance and H19 transcriptional fine regulation.
Bohne F, Langer D, Martiné U, Eider CS, Cencic R, Begemann M, Elbracht M, Bülow L, Eggermann T, Zechner U, Pelletier J, Zabel BU, Enklaar T, Prawitt D., Free PMC Article | 12/17/2016 |
| Kaiso modulates HIF1A gene expression by binding to the methylated HIF1A promoter in a region proximal to the autoregulatory HIF-1 binding site, primarily during hypoxia. | Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.
Pierre CC, Longo J, Bassey-Archibong BI, Hallett RM, Milosavljevic S, Beatty L, Hassell JA, Daniel JM. | 02/6/2016 |
| NF-kappaB response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO and p53 | Transcriptional activation of APAF1 by KAISO (ZBTB33) and p53 is attenuated by RelA/p65.
Koh DI, An H, Kim MY, Jeon BN, Choi SH, Hur SS, Hur MW. | 10/31/2015 |
| KAISO is a regulator of p53-mediated transcription of CDKN1A and apoptotic genes | KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.
Koh DI, Han D, Ryu H, Choi WI, Jeon BN, Kim MK, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, Hur MW., Free PMC Article | 04/25/2015 |
| Data indicate that Kaiso protein participates in the regulation of beta-catenin mRNA expression by interacting with p120-catenin in the lung cancer cell lines. | Kaiso interacts with p120-catenin to regulate β-catenin expression at the transcriptional level.
Liu Y, Dong QZ, Wang S, Xu HT, Miao Y, Wang L, Wang EH., Free PMC Article | 12/6/2014 |